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  "documentTitle": "BenevolentAI | Investor Presentation Deck | 19 slides",
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  "notes": "Includes a biological pathway diagram, a volcano plot for gene expression, and bar charts showing cytokine reduction.",
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      "text": "Selective PDE10 inhibition showed comparable reduction of IL-6 and IL-8 to the positive controls in ex vivo UC biopsies",
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      "text": "Differential RNA expression of PDE10A and GUCY2C: normal vs UC",
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      "text": "PDE10 was experimentally validated as a novel target using ex vivo biopsies from pharmacotherapy resistant UC patients. Inflammatory cytokine release from UC samples significantly reduced with PDE10 inhibition.",
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      "text": "Transcriptomics data support the rationale for PDE10 as a novel target for UC. PDE10 regulates signal transduction by hydrolysing cGMP. PDE10 is significantly upregulated in UC-derived colon and colonic mucosa samples.",
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      "text": "Reduced levels of guanylyl cyclase correlate with increased TNF-a in UC colonic mucosa. cGMP is downregulated in UC. PDE10 is well-studied in CNS disorders but not in inflammation.",
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      "text": "*Brenna et al, 2015",
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      "text": "BEN-8744 - Phosphodiesterase 10 (PDE10) - a novel target for UC",
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