{
  "docId": "019de072-e9f7-73aa-b63d-f50108da815f",
  "docSlug": "8dc30a1d33d144ab07b1459d0ae0e445",
  "documentTitle": "AstraZeneca | Investor Day Presentation Deck | 43 slides",
  "authorId": "astrazeneca",
  "authorName": "AstraZeneca",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2022-06-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 14,
  "pageCount": 43,
  "prevPage": 13,
  "nextPage": 15,
  "slideType": "appendix_methodology",
  "function": "present_framework",
  "density": "dense",
  "nDataPoints": 2,
  "notes": "The slide uses a standard clinical trial flow diagram (randomization process).",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de072-e9f7-73aa-b63d-f50108da815f/14",
  "deckHref": "/decks/019de072-e9f7-73aa-b63d-f50108da815f",
  "deckJsonHref": "/decks/019de072-e9f7-73aa-b63d-f50108da815f.json",
  "deckAnchorHref": "/decks/019de072-e9f7-73aa-b63d-f50108da815f#slide-14",
  "components": [
    {
      "bbox": {
        "h": 0.45,
        "w": 0.92,
        "x": 0.05,
        "y": 0.29
      },
      "kind": "diagram",
      "text": "Trial flow diagram showing patient enrollment, 2:1 randomization, and two treatment arms (T-DXd vs TPC).",
      "attrs": null,
      "subkind": "process",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9afb5d1d-989f-48b8-ba36-5b3a6e47a46e",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.06,
        "w": 0.95,
        "x": 0.03,
        "y": 0.92
      },
      "kind": "disclaimer",
      "text": "T-DXd = trastuzumab deruxtecan; HER2 = human epidermal growth factor receptor 2; HER2-low = human epidermal growth factor receptor 2 low; IHC = immunohistochemistry; ISH = in situ hybridization; mBC = metastatic breast cancer; HR+ = hormone-receptor positive; R = randomised; Q3W = every three weeks; TPC = treatment of physician's choice; PFS = progression-free survival; BICR = blinded independent central review; OS = overall survival; CDK4/6i = cyclin-dependent kinase 4/6 inhibitor.",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "e29248ed-f71a-4ab7-b7d1-5aef956d3f16",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.4,
        "x": 0.05,
        "y": 0.72
      },
      "kind": "list",
      "text": "Stratification factors: Centrally assessed HER2 status, 1 vs 2 prior lines of chemotherapy, HR+ vs HR-",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "e88b5afd-b4eb-47c4-830b-1333ecde298a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.06,
        "w": 0.45,
        "x": 0.03,
        "y": 0.07
      },
      "kind": "title",
      "text": "DESTINY-Breast04 trial design",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "2bd02d4c-3193-4e85-a390-61df994217a7",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.08,
        "w": 0.75,
        "x": 0.03,
        "y": 0.14
      },
      "kind": "title",
      "text": "First randomised Phase III trial of T-DXd for HER2-low mBC - An open label, multicenter trial",
      "attrs": null,
      "subkind": "subtitle",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "26808d8b-f93a-4576-a17b-a31b0d1c9e52",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "clinical-trial-design",
      "slug": null,
      "matchId": "02d2a710-3e98-4d49-b36c-5f009766cfdc",
      "evidence": "Visual flow of patient randomization and treatment arms",
      "confidence": 0.9
    }
  ],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}