{
  "docId": "019de072-e6c6-771e-b24a-5adaac3cef4b",
  "docSlug": "1c626f0801e0e9ad1e805f8e0140c291",
  "documentTitle": "Alkermes | Results Presentation Deck | 26 slides",
  "authorId": "alkermes",
  "authorName": "Alkermes",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2022-06-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 6,
  "pageCount": 26,
  "prevPage": 5,
  "nextPage": 7,
  "slideType": "propose_solution",
  "function": "present_solution",
  "density": "dense",
  "nDataPoints": 0,
  "notes": "The diagram illustrates the binding affinity of Nemvaleukin to the beta/gamma receptor complex (CD122/CD132) while avoiding the alpha receptor (CD25).",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de072-e6c6-771e-b24a-5adaac3cef4b/6",
  "deckHref": "/decks/019de072-e6c6-771e-b24a-5adaac3cef4b",
  "deckJsonHref": "/decks/019de072-e6c6-771e-b24a-5adaac3cef4b.json",
  "deckAnchorHref": "/decks/019de072-e6c6-771e-b24a-5adaac3cef4b#slide-6",
  "components": [
    {
      "bbox": {
        "h": 0.6,
        "w": 0.6,
        "x": 0.38,
        "y": 0.25
      },
      "kind": "image",
      "text": "Diagram showing Nemvaleukin binding to beta/gamma receptors on CD8+ T cells/NK cells, and its exclusion from alpha-receptor-bearing T-reg cells.",
      "attrs": null,
      "subkind": "infographic",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "e5cc47cc-033b-4e95-9d15-950a584e2e16",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.6,
        "w": 0.35,
        "x": 0.05,
        "y": 0.25
      },
      "kind": "list",
      "text": "Preferentially expand cancer-fighting CD8+ T cells and natural killer (NK) cells to potentially improve anti-tumor efficacy. Prevent engagement with the high-affinity IL-2 receptor to mitigate: 1. IL-2-derived expansion of immunosuppressive regulatory T cells (T regs). 2. Activation of vascular endothelial cells, which has been associated with certain side effects of hdIL-2, including vascular leak syndrome.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "dcdd2a9e-ffb2-46ee-bc2b-3d95516c5752",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.3,
        "x": 0.38,
        "y": 0.75
      },
      "kind": "source-note",
      "text": "For illustrative purposes only; T reg: regulatory T cell; NK cell: natural killer cell",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "1b6b838a-61f4-42e2-ad18-a68d2b7c4777",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.8,
        "x": 0.05,
        "y": 0.05
      },
      "kind": "title",
      "text": "Nemvaleukin: Designed to Capture and Expand the Therapeutic Potential of High-Dose IL-2",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "38b2b0cd-87b1-47a1-aee3-a6e08fceb6ae",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 6,
      "from": 5,
      "beatId": "742a23a6-bddc-4625-a92a-7f17683beece",
      "arcName": "The Consultant's Gambit",
      "arcSlug": "consultants-gambit",
      "beatName": "Problem & Complication",
      "beatSlug": "consultants-gambit-problem-complication",
      "evidence": "Slides 5-6 discuss the limitations of current IL-2 therapies and the need for a new solution.",
      "position": 1,
      "confidence": 0.8,
      "parentBeatName": "Complication",
      "parentBeatSlug": "complication"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}