{
  "docId": "019de072-7781-7512-96cc-a2b05ce755c7",
  "docSlug": "b1746432eb5f270eac90273cddb862aa",
  "documentTitle": "Bionomics | Investor Presentation Deck | 38 slides",
  "authorId": "bionomics",
  "authorName": "Bionomics",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2022-04-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 5,
  "pageCount": 38,
  "prevPage": 4,
  "nextPage": 6,
  "slideType": "solution",
  "function": "present_solution",
  "density": "balanced",
  "nDataPoints": 0,
  "notes": "The slide uses a biological process diagram to explain allosteric modulation and a conceptual graph to illustrate how NAMs and PAMs restore normal activity.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de072-7781-7512-96cc-a2b05ce755c7/5",
  "deckHref": "/decks/019de072-7781-7512-96cc-a2b05ce755c7",
  "deckJsonHref": "/decks/019de072-7781-7512-96cc-a2b05ce755c7.json",
  "deckAnchorHref": "/decks/019de072-7781-7512-96cc-a2b05ce755c7#slide-5",
  "components": [
    {
      "bbox": {
        "h": 0.7,
        "w": 0.45,
        "x": 0.52,
        "y": 0.15
      },
      "kind": "chart",
      "text": "Conceptual graph showing hypercholinergic and hypocholinergic disease states relative to normal activity.",
      "attrs": null,
      "subkind": "line",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "f5a613b8-0180-4705-8486-ddb7d2d6b065",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.7,
        "w": 0.45,
        "x": 0.03,
        "y": 0.15
      },
      "kind": "diagram",
      "text": "Mechanism of action showing ACh binding, Ca2+ flow, and allosteric drug binding in the transmembrane domain.",
      "attrs": null,
      "subkind": "process",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "fcf9bce5-8abc-4a87-a386-ec414f5bb090",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.45,
        "x": 0.13,
        "y": 0.88
      },
      "kind": "paragraph",
      "text": "Ca2+ = Calcium ions; ACh = Acetylcholine; NAM = Negative Allosteric Modulator; PAM = Positive Allosteric Modulator; Cholinergic = System associated with memory, selective attention, and emotional processing cognitive functions; PTSD = Post-Traumatic Stress Disorder; CIAS = Cognitive Impairment Associated with Schizophrenia; ADHD = Attention Deficit Hyperactivity Disorder",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "b72fc14c-f07e-4e5b-ac2f-d4717bfa6976",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.65,
        "x": 0.07,
        "y": 0.03
      },
      "kind": "title",
      "text": "A Differentiated Approach: The α7 Nicotinic Acetylcholine Receptor",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "1aee6f63-467c-4936-885a-398280266bb6",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "process",
      "slug": null,
      "matchId": "25fdbe87-3867-4d57-8ab4-0ad00d04fad5",
      "evidence": "The slide uses a numbered sequence (1-4) to explain the biological mechanism of action.",
      "confidence": 0.9
    }
  ],
  "arcBeats": [
    {
      "to": 6,
      "from": 5,
      "beatId": "6ae55fc5-268b-41d1-893d-88fd5f9a266e",
      "arcName": "The Sequoia Pitch",
      "arcSlug": "sequoia-pitch",
      "beatName": "Solution",
      "beatSlug": "sequoia-pitch-solution",
      "evidence": "The solution is presented on pages 5-6, introducing Bionomics' differentiated approach through the α7 Nicotinic Acetylcholine Receptor.",
      "position": 1,
      "confidence": 0.8,
      "parentBeatName": "Turn",
      "parentBeatSlug": "turn"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}