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      "text": "Wang et al. J Pharmacol Exp Ther 373:311–324, May 2020. PAM = Positive allosteric modulator. MSD = A tradename of Merck & Co., Inc., Kenilworth NJ USA",
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      "text": "Entered into in 2014 to develop α7 receptor PAMs targeting cognitive dysfunction associated with Alzheimer’s disease and other central nervous system conditions. Merck funds all R&D activities. Milestone payments of US$20M upfront and US$10M in 2017. Eligible for up to US$465M in additional payments.",
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      "text": "Includes 2 candidates in early-stage Phase 1 safety and biomarker clinical trials. 1st compound completed Phase 1 safety trials. In 2020, a second molecule was advanced by Merck into Phase 1 clinical trials.",
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