{
  "docId": "019de072-1970-7036-9d15-9ffed6304914",
  "docSlug": "3db8307bc8c7b92a71fc075519a1ccaf",
  "documentTitle": "AstraZeneca | Investor Day Presentation Deck | 35 slides",
  "authorId": "astrazeneca",
  "authorName": "AstraZeneca",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2022-02-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 24,
  "pageCount": 35,
  "prevPage": 23,
  "nextPage": 25,
  "slideType": "comparison_table",
  "function": "compare_peers",
  "density": "dense",
  "nDataPoints": 18,
  "notes": "The slide uses a patient image to humanize the clinical data. The comparison focuses on the delta (8.2m) between control/standard and experimental arms.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de072-1970-7036-9d15-9ffed6304914/24",
  "deckHref": "/decks/019de072-1970-7036-9d15-9ffed6304914",
  "deckJsonHref": "/decks/019de072-1970-7036-9d15-9ffed6304914.json",
  "deckAnchorHref": "/decks/019de072-1970-7036-9d15-9ffed6304914#slide-24",
  "components": [
    {
      "bbox": {
        "h": 1,
        "w": 0.35,
        "x": 0,
        "y": 0
      },
      "kind": "image",
      "text": "Patient exercising with dumbbells",
      "attrs": null,
      "subkind": "photo",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "6a73d163-7644-4d97-b5ca-810aeda18971",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.6,
        "x": 0.38,
        "y": 0.96
      },
      "kind": "source-note",
      "text": "1. Mulders et al. N Engl J Med 2013; 368:138-148. Dif. = difference; NR = not reached; HR = hazard ratio.",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "12fb0592-4ecd-4907-940f-9132a870aefc",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.6,
        "x": 0.34,
        "y": 0.35
      },
      "kind": "table",
      "text": "COU-AA-302 (2012) vs PROpel (2022) median rPFS comparison showing 8.2m difference in both.",
      "attrs": null,
      "subkind": "data",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "7f32aded-46cf-4ed4-9dbf-9e877129e4d7",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.6,
        "x": 0.34,
        "y": 0.62
      },
      "kind": "table",
      "text": "PROpel median rPFS breakdown by assessment type (Investigator vs BICR) and HRRm status.",
      "attrs": null,
      "subkind": "data",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "af2a9fed-64d8-4afb-94cd-344c77ff3acc",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.6,
        "x": 0.35,
        "y": 0.05
      },
      "kind": "title",
      "text": "After almost a decade, the addition of Lynparza achieves a similar absolute rPFS improvement compared to the pivotal trial that established abiraterone as first-line SoC",
      "attrs": null,
      "subkind": "action-title",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "df741372-bdd9-4313-98c1-3b8ad5887a1c",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "comparison_frame",
      "slug": null,
      "matchId": "866394b0-c285-474d-847f-84b0aa5c4bf4",
      "evidence": "Direct comparison of two clinical trials to establish parity in efficacy.",
      "confidence": 0.9
    }
  ],
  "arcBeats": [
    {
      "to": 25,
      "from": 23,
      "beatId": "7bf432cb-b1a5-4aae-a899-3cdafdfd475a",
      "arcName": "Problem-Agitate-Solution",
      "arcSlug": "problem-agitate-solution",
      "beatName": "Solution (Provide relief)",
      "beatSlug": "problem-agitate-solution-solution-provide-relief",
      "evidence": "The deck presents the PROpel trial results as a solution to the unmet need in mCRPC.",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": "Resolution",
      "parentBeatSlug": "resolution"
    },
    {
      "to": 24,
      "from": 23,
      "beatId": "9a7ec330-cddf-4aac-8d54-e948ecdab694",
      "arcName": "Problem-Agitate-Solution",
      "arcSlug": "problem-agitate-solution",
      "beatName": "Desire",
      "beatSlug": "aida-desire",
      "evidence": "The deck creates desire for the PROpel approach by highlighting its benefits and potential as a new standard of care.",
      "position": 4,
      "confidence": 0.8,
      "parentBeatName": "Evidence",
      "parentBeatSlug": "evidence"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}