{
  "docId": "019de072-122c-721c-8b62-3522a74ffc66",
  "docSlug": "bcca0cb7dade19d9f637477238714c68",
  "documentTitle": "Aeglea BioTherapeutics | Investor Presentation Deck | 33 slides",
  "authorId": "aeglea-biotherapeutics",
  "authorName": "Aeglea BioTherapeutics",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2022-02-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 6,
  "pageCount": 33,
  "prevPage": 5,
  "nextPage": 7,
  "slideType": "problem_statement",
  "function": "frame_problem",
  "density": "overcrowded",
  "nDataPoints": 3,
  "notes": null,
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de072-122c-721c-8b62-3522a74ffc66/6",
  "deckHref": "/decks/019de072-122c-721c-8b62-3522a74ffc66",
  "deckJsonHref": "/decks/019de072-122c-721c-8b62-3522a74ffc66.json",
  "deckAnchorHref": "/decks/019de072-122c-721c-8b62-3522a74ffc66#slide-6",
  "components": [
    {
      "bbox": {
        "h": 0.15,
        "w": 0.8,
        "x": 0.105,
        "y": 0.615
      },
      "kind": "list",
      "text": "Prominent and progressive neurological manifestations. Impaired mobility due to characteristic spastic diplegia. Seizures are a common feature.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "68995b59-5ed0-4c47-a85a-90e150d7aa9d",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.8,
        "x": 0.105,
        "y": 0.795
      },
      "kind": "list",
      "text": "May be initially misdiagnosed as cerebral palsy or hereditary spastic paraplegia",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9b3abce4-ed41-47f3-9b6e-af4392a2b2df",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.8,
        "x": 0.105,
        "y": 0.435
      },
      "kind": "list",
      "text": "Typically presents at ~2-4 years of age; can be later. Developmental delay with increasing intellectual disability. Failure to thrive and short stature.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "abbd7393-8c6b-4fcb-9ccb-aa63025804d0",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.8,
        "x": 0.105,
        "y": 0.205
      },
      "kind": "list",
      "text": "Autosomal recessive disorder of arginine metabolism due to ARG1 enzyme deficiency. Recent genetic prevalence data suggests >2500 patients worldwide (>700 in Europe, >=250 in US).",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "b23b60ac-89ea-4f63-9ce3-86c00887d66a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.65,
        "x": 0.325,
        "y": 0.945
      },
      "kind": "source-note",
      "text": "1. Aeglea Data on File. 2. Huemer M, et al. J Inherit Metab Dis. 2016;39:331-340. 3.Burrage LC, et al. Hum Mol Genet. 2015;24:6417-6427. 4. Carvalho DR, et al. Pediatr Neurol. 2012;46:369-374. 5.Carvalho DR et al. Gene 2012; 509(1): 124-130.",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a5f63ddc-5245-4d08-8d37-d025411ef539",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.055,
        "w": 0.385,
        "x": 0.105,
        "y": 0.105
      },
      "kind": "title",
      "text": "Arginase 1 Deficiency (ARG1-D)",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "472b4b02-6cd1-4b9f-a197-422bb8ba3ff9",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 7,
      "from": 6,
      "beatId": "c8c7da75-4a0c-483f-94bc-e6a4117ad71e",
      "arcName": "Problem-Agitate-Solution",
      "arcSlug": "problem-agitate-solution",
      "beatName": "Problem Statement",
      "beatSlug": null,
      "evidence": "The deck clearly states the problem of Arginase 1 Deficiency and its effects on patients",
      "position": 0,
      "confidence": 0.8,
      "parentBeatName": null,
      "parentBeatSlug": null
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}