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  "notes": "The chart shows dose-response curves for VG-2862 concentration vs. pSYK activation signal, comparing 'No Fab' (control) against four different Fabs.",
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      "text": "Engineered cell line over-expressing hTREM2 and hDAP12 for pSYK assay readout. All Fabs bind to extracellular domain of TREM2 with similar low nM affinity. Fabs bind to TREM2 but do not activate downstream signaling (pSYK). Fab activation interference consistent with direct small molecule binding to TREM2. Direct binding of small molecule also demonstrated in TREM2/DAP12-loaded nanodiscs using 19F NMR",
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      "text": "Direct Binding of Small Molecule Agonist to TREM2",
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