{
  "docId": "019de072-0f48-75dc-8e26-6c36719c246a",
  "docSlug": "59aa3600901f9a5fdbc1ca4ce261b5cc",
  "documentTitle": "Vigil Neuroscience | IPO Presentation Deck | 54 slides",
  "authorId": "vigil-neuroscience",
  "authorName": "Vigil Neuroscience",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investment_bank",
  "sourceTypeLabel": "Investment bank",
  "presentationDate": "2022-01-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7794254,
  "pageNumber": 34,
  "pageCount": 54,
  "prevPage": 33,
  "nextPage": 35,
  "slideType": "market_sizing",
  "function": "size_opportunity",
  "density": "balanced",
  "nDataPoints": 6,
  "notes": "The slide uses a top-down funnel approach to narrow the market from general leukodystrophies to the specific ALSP indication.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de072-0f48-75dc-8e26-6c36719c246a/34",
  "deckHref": "/decks/019de072-0f48-75dc-8e26-6c36719c246a",
  "deckJsonHref": "/decks/019de072-0f48-75dc-8e26-6c36719c246a.json",
  "deckAnchorHref": "/decks/019de072-0f48-75dc-8e26-6c36719c246a#slide-34",
  "components": [
    {
      "bbox": {
        "h": 0.55,
        "w": 0.85,
        "x": 0.08,
        "y": 0.2
      },
      "kind": "diagram",
      "text": "U.S. adult onset leukodystrophies: ~16,500 (incidence); ~99,000 (prevalence) -> U.S. ALSP: ~1,000-2,000 (incidence); ~10,000 (prevalence) -> Potentially significant U.S. commercial opportunity",
      "attrs": null,
      "subkind": "funnel",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a92e1992-b33a-48ea-bc8e-011eb1755521",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.08,
        "w": 0.68,
        "x": 0.24,
        "y": 0.75
      },
      "kind": "paragraph",
      "text": "EU27+UK prevalence: ~15,000; Japan prevalence: ~4,000",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "641405fc-dd7f-40bd-a9d1-1e620dbb09f3",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.6,
        "x": 0.05,
        "y": 0.88
      },
      "kind": "source-note",
      "text": "1. Sassi et al Neurobiol Aging 2018; 2. Ahmed et al. J Neurol Neurosurg Psych 2014; 3. Lynch et al. Neurogenetics 2015; 4. Assumes same prevalence as U.S.",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "5a6877be-7843-47fd-8987-0c32e7a2e26c",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.7,
        "x": 0.05,
        "y": 0.1
      },
      "kind": "title",
      "text": "ALSP – Significant Commercial Potential for VGL101",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "4e064af3-1fa3-4e49-8c35-7bff4bf84f0f",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Market Segmentation Pyramid",
      "slug": "market-segmentation-pyramid",
      "agent": null,
      "layer": "slide",
      "matchId": "3a2daca5-0e63-42c7-a7c2-1afb69f27b27",
      "evidence": "U.S. adult onset leukodystrophies: ~16,500 (incidence); ~99,000 (prevalence)",
      "confidence": 0.6
    }
  ],
  "frameworks": [
    {
      "name": "market-segmentation-pyramid",
      "slug": null,
      "matchId": "6f502191-9070-4b56-957a-56ff7334b4a6",
      "evidence": "The slide uses a funnel-like structure to segment the total addressable market into a specific target indication.",
      "confidence": 0.85
    }
  ],
  "arcBeats": [
    {
      "to": 34,
      "from": 34,
      "beatId": "d2e958a4-301b-484e-a6f0-bd497ddeb93a",
      "arcName": "The Sequoia Pitch",
      "arcSlug": "sequoia-pitch",
      "beatName": "Market Size",
      "beatSlug": "sequoia-pitch-market-size",
      "evidence": "The document provides an overview of the commercial potential for VGL101 in ALSP.",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": "Evidence",
      "parentBeatSlug": "evidence"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}