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  "documentTitle": "Vigil Neuroscience | IPO Presentation Deck | 54 slides",
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  "authorName": "Vigil Neuroscience",
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      "text": "Epidemiology: 10% adult-onset leukodystrophies (global): 3 per 100,000 or ~10K patients in U.S. Affects both genders. Mean age onset 43 years (range 18–78). Genetics: Caused by CSF1R gene mutations. Autosomal dominant inheritance.",
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      "text": "Clinical Picture/Unmet Need: Neuropsychiatric: behavioral changes, executive dysfunction, depression, anxiety, psychosis, and progressive cognitive decline. Motor/Gait: ataxia, apraxia, and pyramidal dysfunction (spasticity). Parkinsonism: resting tremor, rigidity, bradykinesia, and postural instability. Other neurologic: epilepsy is common, especially in late stages.",
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      "text": "Treatment: No approved products and no experimental treatments. Treatment is mainly supportive, palliative care and symptom alleviation. Limited experience and inconclusive efficacy with hematopoietic stem-cell transplantation (HSCT).",
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      "text": "Lakshmanan et al, Neurol Genet 2017; Hayer et al, Neurology 2018; Lynch et al. J Neural Neurosurg Psychiatry 2016; Konno et al. Neurol 2018; Ahmed et al. J Neurol Neurosurg Psych 2014",
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