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  "documentTitle": "Alkermes | Investor Conference Presentation Deck | 36 slides",
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  "notes": "The slide includes a molecular visualization of the HDAC1/2-CoREST complex.",
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      "text": "Molecular structure of HDAC1/2 in the CoREST complex",
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      "text": "HDAC inhibitors increase accessibility of DNA for transcription of genes associated with synaptogenesis. Many neurological disorders are characterized by synaptic pathology. Targeting the synapse may slow progression and preserve cognitive and functional abilities in a range of diseases. ALKS 1140 selectively targets HDAC1/2 bound in the CoREST complex, which is directly involved in repression of prosynaptic genes. ALKS 1140 increased dendritic spines and synapses; improved synaptic function in areas associated with memory and cognition in preclinical models.",
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      "text": "Fuller et al. ACS Chem. Neurosci. 2019;10(3):1729-1743",
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