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  "documentTitle": "Kymera | Investor Day Presentation Deck | 105 slides",
  "authorId": "kymera",
  "authorName": "Kymera",
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  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2021-12-01 00:00:00",
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  "pageNumber": 76,
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  "slideType": "problem_statement",
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  "density": "dense",
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  "notes": "The chart is a waterfall plot showing dependency scores across various cell lines, illustrating that p53-wildtype cells are highly dependent on MDM2.",
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  "slideHref": "/slides/019de071-eb84-776b-8e7d-ce40a476afec/76",
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      "kind": "chart",
      "text": "Dependency of p53WT cells on MDM2",
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      "kind": "diagram",
      "text": "Biological pathway showing stressor-induced p53 activation, MDM2-mediated ubiquitination and degradation, and p53-mediated tumor suppression targets.",
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      "kind": "list",
      "text": "p53 is NOT mutated in almost 50% of tumors; MDM2 overexpression and amplification can inactivate p53; Large opportunity in wide variety of cancers",
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      "text": "Graph generated with data obtained from DepMap.org",
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      "kind": "title",
      "text": "MDM2 is the E3 Ligase that Modulates P53, the Largest Tumor Suppressor",
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      "name": "Cost Of Inaction",
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      "bestFor": "Urgent budget requests, compliance, risk mitigation",
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      "evidence": "The deck presents the limitations of current approaches and the benefits of Kymera's MDM2 degrader.",
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      "objective": "To highlight the potential consequences of not adopting TPD, specifically in the context of MDM2 and p53.",
      "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
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      "description": "Quantify what happens if the audience does nothing"
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