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  "notes": "The diagram illustrates a complex signaling loop involving STAT3, cytokines, and various cell types (leukocytes, endothelial, stromal) leading to disease states.",
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      "text": "STAT3 is activated by multiple tyrosine kinases and plays a critical role in the signaling of cytokines, hormones, and growth factors including IL-6, IL-21, IL-11, OSM, TGF-β, VEGF. STAT3 gain-of-function mutations lead to a poly-autoimmunity with clinical manifestations that include interstitial lung disease (ILD), arthritis, scleroderma and eczema. Increased STAT3 activation is associated with disease severity in chronic inflammation including SSc, RA, AS, MS, IBD, Psoriasis. STAT3 activation is also implicated in conditions defined by intense stromal remodeling in the absence of overt inflammation, e.g. IPF, PAH, NAFLD, and Diabetic Kidney Disease",
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