{
  "docId": "019de071-eb84-776b-8e7d-ce40a476afec",
  "docSlug": "ee62a94395a2a2b10c5eb93465b3bf02",
  "documentTitle": "Kymera | Investor Day Presentation Deck | 105 slides",
  "authorId": "kymera",
  "authorName": "Kymera",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2021-12-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 59,
  "pageCount": 105,
  "prevPage": 58,
  "nextPage": 60,
  "slideType": "key_messages",
  "function": "present_framework",
  "density": "dense",
  "nDataPoints": 1,
  "notes": "The slide uses a biological pathway diagram to explain the mechanism of action for a therapeutic target.",
  "elementsJson": null,
  "metadataConfidence": 0.95,
  "imagePath": null,
  "slideHref": "/slides/019de071-eb84-776b-8e7d-ce40a476afec/59",
  "deckHref": "/decks/019de071-eb84-776b-8e7d-ce40a476afec",
  "deckJsonHref": "/decks/019de071-eb84-776b-8e7d-ce40a476afec.json",
  "deckAnchorHref": "/decks/019de071-eb84-776b-8e7d-ce40a476afec#slide-59",
  "components": [
    {
      "bbox": {
        "h": 0.5,
        "w": 0.3,
        "x": 0.05,
        "y": 0.15
      },
      "kind": "diagram",
      "text": "STAT3 as a Target pathway diagram",
      "attrs": null,
      "subkind": "process",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8190ce84-bb14-4169-a1ff-e15c88fa49d3",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.75,
        "w": 0.25,
        "x": 0.38,
        "y": 0.15
      },
      "kind": "diagram",
      "text": "Central mechanism diagram showing STAT3 in cancer cells leading to cytokines and immune/endothelial cell effects",
      "attrs": null,
      "subkind": "process",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c00ecfb1-7b08-422d-8548-e81fb23cc2d5",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.3,
        "x": 0.05,
        "y": 0.65
      },
      "kind": "list",
      "text": "High degree of validation of JAK-STAT pathway in oncology and immuno-oncology supported by >25k publications; Traditionally undrugged target; First-in-class opportunity to address STAT3 driven pathology",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ceb73562-6db4-4e03-bc53-bf6e88b0d0ff",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.75,
        "w": 0.3,
        "x": 0.65,
        "y": 0.15
      },
      "kind": "list",
      "text": "Tumor Cell Intrinsic: Hyperactivation of STAT3... Opportunities in STAT3-dependent malignancies... Tumor Cell Extrinsic: STAT3 promotes differentiation... Opportunities in multiple heme and solid tumor indications...",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "fa580c3e-d376-47c2-8a59-b4fa7d9602dd",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.08,
        "w": 0.9,
        "x": 0.05,
        "y": 0.03
      },
      "kind": "title",
      "text": "STAT3 Has Unique Tumor Cell Intrinsic and Extrinsic Mechanisms",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "74c5a5eb-4f0f-4839-a430-55f759d673ea",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "List presentation",
      "slug": "list-presentation",
      "agent": null,
      "layer": "slide",
      "matchId": "84f19c50-7d75-479d-8bb5-9fdf6a08a0c9",
      "evidence": "The slide contains a list/bullet of Tumor Cell Intrinsic and Extrinsic Mechanisms.",
      "confidence": 0.9
    }
  ],
  "frameworks": [
    {
      "name": "biological-pathway-model",
      "slug": null,
      "matchId": "cd55ab4e-3fe7-4bc7-acb1-86e3db75433c",
      "evidence": "Visual representation of cellular signaling pathways",
      "confidence": 0.8
    }
  ],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}