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  "documentTitle": "Kymera | Investor Day Presentation Deck | 105 slides",
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  "presentationDate": "2021-12-01 00:00:00",
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  "notes": "The slide illustrates a biological pathway diagram showing how IRAKiMiDs degrade both IRAK4 and IMiD substrates to inhibit proliferation and survival in cancer cells.",
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      "text": "Comparison of IMiD Degrader vs IRAKiMiD Degrader mechanism.",
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      "text": "Biological pathway diagram showing receptors, signaling molecules, and the effect of degraders on pathways leading to proliferation and survival.",
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      "text": "Single-agent therapies that target activated NFkB signaling in DLBCL show limited activity in preclinical or clinical settings. Redundant NFkB pathway activation and downregulation of Type 1 IFN is common in MYD88MT lymphoma, supporting need to seek combination therapies. Targeting simultaneous degradation of IRAK4 and IMiD substrates Ikaros and Aiolos shows synergistic activity in MYD88MT models, supporting this targeted combination",
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      "text": "Adapted from Yang et al. (2012) Cancer Cell 21, 6, pp723-737",
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      "text": "IRAKiMiDs are Potent Degraders of IRAK4 and IMiD Substrates Targeting Redundant Pro-survival Pathways in MYD88MT DLBCL",
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