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  "notes": "The left chart is a volcano plot showing selectivity; the right chart is a dose-response curve comparing the degrader to a kinase inhibitor.",
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      "text": "KT-474 DC50 = 2.1 nM in human immune cells; KT-474 only degraded IRAK4 in human immune cells at concentration 10-fold above the DC90; KT-474 better able to inhibit IL-6 under both LPS and LPS + IL-1β than clinically active IRAK4 SM kinase inhibitor PF-06550833",
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