{
  "docId": "019de071-eb84-776b-8e7d-ce40a476afec",
  "docSlug": "ee62a94395a2a2b10c5eb93465b3bf02",
  "documentTitle": "Kymera | Investor Day Presentation Deck | 105 slides",
  "authorId": "kymera",
  "authorName": "Kymera",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2021-12-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 23,
  "pageCount": 105,
  "prevPage": 22,
  "nextPage": 24,
  "slideType": "key_takeaways",
  "function": "analyze_data",
  "density": "dense",
  "nDataPoints": 120,
  "notes": "Data source: Alavi et al., Society for Investigative Dermatology Annual Meeting, 2021.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de071-eb84-776b-8e7d-ce40a476afec/23",
  "deckHref": "/decks/019de071-eb84-776b-8e7d-ce40a476afec",
  "deckJsonHref": "/decks/019de071-eb84-776b-8e7d-ce40a476afec.json",
  "deckAnchorHref": "/decks/019de071-eb84-776b-8e7d-ce40a476afec#slide-23",
  "components": [
    {
      "bbox": {
        "h": 0.7,
        "w": 0.25,
        "x": 0.42,
        "y": 0.18
      },
      "kind": "chart",
      "text": "IRAK4 correlation heatmap (IF/MS) and lesion vs non-lesion fold change heatmap.",
      "attrs": null,
      "subkind": "heatmap",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8879ed30-34b6-4ccc-8528-574dd51b7dbd",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.7,
        "w": 0.25,
        "x": 0.12,
        "y": 0.18
      },
      "kind": "chart",
      "text": "Scaled expression heatmap of transcripts across lesion, peri-lesion, non-lesion, and healthy skin.",
      "attrs": null,
      "subkind": "heatmap",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9e07bed6-46e9-4b80-9730-ec4be94ce06e",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.5,
        "w": 0.25,
        "x": 0.7,
        "y": 0.25
      },
      "kind": "list",
      "text": "Upregulation of TLRs, IL-1β/IL-36, MYD88, and multiple additional drivers of inflammation that all correlate with IRAK4 protein expression. Highlights potential of IRAK4 targeting to treat diseases like HS characterized by marked pleiotropic inflammation.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9d7a7f96-d8e9-4935-bbe3-5f1a101a9868",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.2,
        "x": 0.75,
        "y": 0.9
      },
      "kind": "source-note",
      "text": "Alavi et al., Society for Investigative Dermatology Annual Meeting, 2021",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "1fe52d46-b3d9-4208-9835-214277159009",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.9,
        "x": 0.05,
        "y": 0.05
      },
      "kind": "title",
      "text": "Multiple Proinflammatory Transcripts Are Upregulated and Correlate with IRAK4 Protein Levels in HS Skin Lesions",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "0fed952b-57ce-412d-81db-759e1f311447",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "2x2 matrix",
      "slug": "matrix-2x2",
      "agent": null,
      "layer": "slide",
      "matchId": "e988ad25-e952-4980-895f-eb9ea441196d",
      "evidence": "The slide includes heatmap charts which could suggest a matrix, but it's not clear if it's a 2x2 matrix.",
      "confidence": 0.7
    },
    {
      "name": "Heatmap matrix",
      "slug": "heatmap-matrix",
      "agent": null,
      "layer": "slide",
      "matchId": "d055d028-ba45-4c45-b0e7-05be78065c4c",
      "evidence": "The slide contains 'Scaled expression heatmap of transcripts across lesion, peri-lesion, non-lesion, and healthy skin.' and 'IRAK4 correlation heatmap (IF/MS) and lesion vs non-lesion fold change heatmap.'",
      "confidence": 0.8
    }
  ],
  "frameworks": [],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}