{
  "docId": "019de071-dd7f-730a-8977-e46a36e30dcf",
  "docSlug": "abc22aebd2d55a5159142df321cabcee",
  "documentTitle": "Bionomics | IPO Presentation Deck | 38 slides",
  "authorId": "bionomics",
  "authorName": "Bionomics",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investment_bank",
  "sourceTypeLabel": "Investment bank",
  "presentationDate": "2021-12-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7391304,
  "pageNumber": 36,
  "pageCount": 38,
  "prevPage": 35,
  "nextPage": 37,
  "slideType": "solution",
  "function": "present_solution",
  "density": "dense",
  "nDataPoints": 8,
  "notes": "The slide uses a combination of a line chart for data and a process flow diagram to explain the mechanism of action.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de071-dd7f-730a-8977-e46a36e30dcf/36",
  "deckHref": "/decks/019de071-dd7f-730a-8977-e46a36e30dcf",
  "deckJsonHref": "/decks/019de071-dd7f-730a-8977-e46a36e30dcf.json",
  "deckAnchorHref": "/decks/019de071-dd7f-730a-8977-e46a36e30dcf#slide-36",
  "components": [
    {
      "bbox": {
        "h": 0.6,
        "w": 0.18,
        "x": 0.02,
        "y": 0.16
      },
      "kind": "callout",
      "text": "BNC210 blood-brain barrier penetration and nicotinic receptor target engagement in humans",
      "attrs": null,
      "subkind": "primary",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "767be2b4-5878-4404-a763-5ad1901ec1bf",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.55,
        "w": 0.38,
        "x": 0.21,
        "y": 0.15
      },
      "kind": "chart",
      "text": "BNC210 Reduced Nicotine-induced EEG Responses",
      "attrs": null,
      "subkind": "line",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9d1d3391-6c4f-483d-b13e-cb3ca5aa0fc0",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.45,
        "w": 0.3,
        "x": 0.65,
        "y": 0.18
      },
      "kind": "diagram",
      "text": "Activation of nicotinic receptors in the brain induces EEG response -> alpha4beta2 and alpha7 receptors are the major nAChR populations targeted -> BNC210 daily oral dosing reduced nicotine-induced EEG in the alpha2 band",
      "attrs": null,
      "subkind": "process",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "050627c6-c2d1-4955-9470-a30330b56fdf",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.25,
        "x": 0.11,
        "y": 0.88
      },
      "kind": "disclaimer",
      "text": "nAChR = Nicotinic Acetylcholine Receptor; EEG = Electroencephalography; * p-value less than 0.05; ** p-value less than 0.01",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "463f0576-d641-482d-ae5b-a9ab367e1622",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.08,
        "w": 0.75,
        "x": 0.2,
        "y": 0.78
      },
      "kind": "source-note",
      "text": "Observed reduction in EEG response, potentially due to BNC210's negative allosteric modulation of the alpha7 receptors",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "45930a47-9dc0-4c89-8ab3-d2ac2267126c",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.6,
        "x": 0.05,
        "y": 0.03
      },
      "kind": "title",
      "text": "Mechanistic Validation of BNC210 as Evidenced by EEG Response",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "81d6898a-8d06-4155-aace-441a2d3ef6b1",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "causal-chain",
      "slug": null,
      "matchId": "e1f4aef8-a80d-4039-8b7c-031b019a0355",
      "evidence": "The process flow diagram illustrates the causal link between receptor activation and the observed EEG reduction.",
      "confidence": 0.8
    }
  ],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}