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      "text": "Age ≥2yo and received ONC201 under studies ONC006, ONC013, ONC014, ONC016, or ONC018\nDiffuse glioma with a known H3K27M mutation and involvement of a midline structure of the brain\nProgressive and measurable disease on contrast-enhanced brain MRI by RANO-High Grade Glioma (HGG) criteria\nPrior therapy with at least radiation\nWashouts prior to first ONC201 dose:\nRadiation: 90 days\nTemozolomide: 23 days / Antibodies (e.g., bevacizumab): 42 days / Other anticancer therapies: 28 days\nBaseline Performance Status ≥60\nCorticosteroids stable or decreasing for at least 3 days prior to baseline scan\nExcluded: DIPG, primary spinal tumors, atypical and non-astrocytic histologies, leptomeningeal spread, CSF dissemination",
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