{
  "docId": "019de071-be30-70fc-a858-8f20c51da6b3",
  "docSlug": "a62013e96cbc38ce4e129c5b57bb4496",
  "documentTitle": "Chimerix | Investor Conference Presentation Deck | 32 slides",
  "authorId": "chimerix",
  "authorName": "Chimerix",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2021-11-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 28,
  "pageCount": 32,
  "prevPage": 27,
  "nextPage": 29,
  "slideType": "before_after",
  "function": "illustrate_case",
  "density": "dense",
  "nDataPoints": 16,
  "notes": "The slide uses a dual-axis line chart to correlate tumor size reduction with performance status improvement, supported by longitudinal MRI scans.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de071-be30-70fc-a858-8f20c51da6b3/28",
  "deckHref": "/decks/019de071-be30-70fc-a858-8f20c51da6b3",
  "deckJsonHref": "/decks/019de071-be30-70fc-a858-8f20c51da6b3.json",
  "deckAnchorHref": "/decks/019de071-be30-70fc-a858-8f20c51da6b3#slide-28",
  "components": [
    {
      "bbox": {
        "h": 0.45,
        "w": 0.55,
        "x": 0.05,
        "y": 0.45
      },
      "kind": "chart",
      "text": "Performance Status (PS) and Tumor Size over 24 months",
      "attrs": null,
      "subkind": "line",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "6e54d3d4-2dec-4261-a29c-943dcb43d540",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.25,
        "x": 0.68,
        "y": 0.07
      },
      "kind": "image",
      "text": "Pre-ONC201 baseline MRI",
      "attrs": null,
      "subkind": "photo",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "18577a2a-62ff-4616-bbc8-9e8dde95153b",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.25,
        "x": 0.68,
        "y": 0.38
      },
      "kind": "image",
      "text": "9 months on ONC201 MRI",
      "attrs": null,
      "subkind": "photo",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "217b1f8e-2b15-44ce-92e8-af7df2499754",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.25,
        "x": 0.68,
        "y": 0.68
      },
      "kind": "image",
      "text": "18 months on ONC201 MRI",
      "attrs": null,
      "subkind": "photo",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3fbe0d62-fd08-4f38-b106-81a40f8c6c68",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.6,
        "x": 0.05,
        "y": 0.15
      },
      "kind": "list",
      "text": "8-year-old thalamic H3.3 K27M DMG initially diagnosed in May 2018\nFirst-line therapy: radiation, dasatinib, everolimus and bevacizumab\nSecond-line therapy: 375mg weekly ONC201 monotherapy initiated Apr 2019 following progression on first-line therapy\nClinical and radiographic improvement over >2 years of therapy",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "4239f773-59d1-4f93-bbba-a9e5c07f305a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.3,
        "x": 0.05,
        "y": 0.05
      },
      "kind": "title",
      "text": "Pediatric Case Study",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "7a4827a3-9b4f-4b9b-8a00-197157a89dc3",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Before-After-Bridge",
      "slug": "before-after-bridge",
      "agent": "Storyteller",
      "layer": "slide",
      "matchId": "ab1a121b-5f52-403a-b819-623dbd252fa5",
      "evidence": "image/photo: Pre-ONC201 baseline MRI, image/photo: 18 months on ONC201 MRI, image/photo: 9 months on ONC201 MRI",
      "confidence": 0.7
    }
  ],
  "frameworks": [
    {
      "name": "before-after-framing",
      "slug": null,
      "matchId": "59e51635-b44e-44ea-ba29-0a97c5752d20",
      "evidence": "The slide contrasts the patient's state before and during ONC201 therapy using longitudinal clinical data and imaging.",
      "confidence": 0.95
    }
  ],
  "arcBeats": [
    {
      "to": 32,
      "from": 22,
      "beatId": "b94e1c59-1634-4aae-b2ea-f66697bc962f",
      "arcName": "Problem-Agitate-Solution",
      "arcSlug": "problem-agitate-solution",
      "beatName": "Solution",
      "beatSlug": "problem-agitate-solution-solution-provide-relief",
      "evidence": "The presentation provides a solution in the form of ONC201's clinical efficacy",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": "Resolution",
      "parentBeatSlug": "resolution"
    }
  ],
  "loops": [
    {
      "to": 29,
      "from": 28,
      "name": "Before After",
      "slug": "21-before-after",
      "bestFor": "Product demos, process improvements, ROI justification",
      "matchId": "b2e1809f-a1eb-4eb3-b691-af8f4ece2bb3",
      "evidence": "The presentation provides case studies",
      "position": 1,
      "objective": "Show before-after cases",
      "structure": "The Old Way (Pain) -> The Moment of Change -> The New Way (Glory) -> The Measurable Delta",
      "confidence": 0.6,
      "description": "Show the dramatic contrast between the old way and the new way through side-by-side comparison"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}