{
  "docId": "019de071-be30-70fc-a858-8f20c51da6b3",
  "docSlug": "a62013e96cbc38ce4e129c5b57bb4496",
  "documentTitle": "Chimerix | Investor Conference Presentation Deck | 32 slides",
  "authorId": "chimerix",
  "authorName": "Chimerix",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2021-11-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 27,
  "pageCount": 32,
  "prevPage": 26,
  "nextPage": 28,
  "slideType": "appendix_data",
  "function": "analyze_data",
  "density": "dense",
  "nDataPoints": 40,
  "notes": "The plot shows individual patient responses; asterisks indicate change > 100%.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de071-be30-70fc-a858-8f20c51da6b3/27",
  "deckHref": "/decks/019de071-be30-70fc-a858-8f20c51da6b3",
  "deckJsonHref": "/decks/019de071-be30-70fc-a858-8f20c51da6b3.json",
  "deckAnchorHref": "/decks/019de071-be30-70fc-a858-8f20c51da6b3#slide-27",
  "components": [
    {
      "bbox": {
        "h": 0.65,
        "w": 0.6,
        "x": 0.36,
        "y": 0.22
      },
      "kind": "chart",
      "text": "Waterfall plot of best % change in SPD from baseline",
      "attrs": null,
      "subkind": "waterfall",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "7121dc1e-e460-416b-bb99-b08bcc6f6a4c",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.35,
        "x": 0.05,
        "y": 0.28
      },
      "kind": "list",
      "text": "Responses observed across age groups: <18 years: 1/4 (25%); 18-40 years: 5/32 (16%); ≥40 years: 4/14 (29%). RANO-HGG response of 8-year-old subject confirms activity in this population",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9042e835-55a0-4b73-b280-bf994cea0996",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.6,
        "x": 0.36,
        "y": 0.86
      },
      "kind": "source-note",
      "text": "* Change > 100%, SPD=sum of products of perpendicular diameters (target enhancing lesions per BICR) Only patients with measurable target enhancing lesions at both baseline and post-baseline are included.",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8c0b1419-4a97-4b81-a203-b7008102660a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.35,
        "x": 0.05,
        "y": 0.11
      },
      "kind": "title",
      "text": "Waterfall Plot (RANO-HGG) Stratified by Age",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "f871df8e-c81f-4656-875d-25514953f047",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Waterfall chart",
      "slug": "waterfall-chart",
      "agent": null,
      "layer": "slide",
      "matchId": "0ec5024c-8152-4a52-96ab-a48f9df4e898",
      "evidence": "chart/waterfall: Waterfall plot of best % change in SPD from baseline",
      "confidence": 0.9
    }
  ],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 32,
      "from": 22,
      "beatId": "b94e1c59-1634-4aae-b2ea-f66697bc962f",
      "arcName": "Problem-Agitate-Solution",
      "arcSlug": "problem-agitate-solution",
      "beatName": "Solution",
      "beatSlug": "problem-agitate-solution-solution-provide-relief",
      "evidence": "The presentation provides a solution in the form of ONC201's clinical efficacy",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": "Resolution",
      "parentBeatSlug": "resolution"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}