{
  "docId": "019de071-4e1f-74a8-b040-3577ed32c01f",
  "docSlug": "716a1960d23114ac9a8076dbc94bca80",
  "documentTitle": "Tenaya Therapeutics | IPO Presentation Deck | 36 slides",
  "authorId": "tenaya-therapeutics",
  "authorName": "Tenaya Therapeutics",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investment_bank",
  "sourceTypeLabel": "Investment bank",
  "presentationDate": "2021-07-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7843866,
  "pageNumber": 17,
  "pageCount": 36,
  "prevPage": 16,
  "nextPage": 18,
  "slideType": "solution",
  "function": "present_solution",
  "density": "dense",
  "nDataPoints": 2,
  "notes": "The slide uses two distinct charts to show tissue specificity (bar chart) and functional efficacy (line chart with error bars).",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de071-4e1f-74a8-b040-3577ed32c01f/17",
  "deckHref": "/decks/019de071-4e1f-74a8-b040-3577ed32c01f",
  "deckJsonHref": "/decks/019de071-4e1f-74a8-b040-3577ed32c01f.json",
  "deckAnchorHref": "/decks/019de071-4e1f-74a8-b040-3577ed32c01f#slide-17",
  "components": [
    {
      "bbox": {
        "h": 0.4,
        "w": 0.4,
        "x": 0.05,
        "y": 0.45
      },
      "kind": "chart",
      "text": "Relative Expression in Heart, Skeletal, Brain, Liver",
      "attrs": null,
      "subkind": "bar-grouped",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "2eebe333-32d9-40dd-9b0f-72a2ed0a1e10",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.4,
        "w": 0.4,
        "x": 0.55,
        "y": 0.45
      },
      "kind": "chart",
      "text": "Ejection Fraction (%) over Weeks Post-Injection",
      "attrs": null,
      "subkind": "line",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "7ecf4fe0-6697-4346-a3ea-10393df62a52",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.45,
        "x": 0.05,
        "y": 0.25
      },
      "kind": "list",
      "text": "High selectivity for heart vs other organs; 2x-3x higher MYBPC3 mRNA expression with proprietary Tenaya promoter vs standard cTnT promoter; Performance also confirmed in hiPSC-CMs and tested in NHPs",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a17bf8cd-98d7-48ff-a6b9-f50541e2a4ca",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.4,
        "x": 0.55,
        "y": 0.25
      },
      "kind": "list",
      "text": "Animals treated at 3 months of age; Significantly better heart function in head-to-head comparison of Tenaya construct vs historical construct in relevant disease model",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "da7356c7-a6fe-415f-b52d-628c52a12d23",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.08,
        "w": 0.9,
        "x": 0.05,
        "y": 0.08
      },
      "kind": "title",
      "text": "Product Differentiation and Improved Results from Proprietary Cardiac-Specific Promoter and Cassette Engineering Efforts",
      "attrs": null,
      "subkind": "action-title",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ec4f7245-73cf-41c3-8210-b1d5c9e6b8fd",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.4,
        "x": 0.05,
        "y": 0.03
      },
      "kind": "title",
      "text": "MYBPC3 Gene Therapy Program",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "d21ecce2-bbd3-4424-aac7-c79001c8c299",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Comparison frame",
      "slug": "comparison-frame",
      "agent": null,
      "layer": "slide",
      "matchId": "ce12575b-1da4-4bb8-8a1d-2d7a647fbc82",
      "evidence": "Animals treated at 3 months of age; Significantly better heart function in head-to-head comparison of Tenaya construct vs historical construct in relevant disease model",
      "confidence": 0.6
    }
  ],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 18,
      "from": 13,
      "beatId": "bfe54e44-7b0c-4c52-9e6e-5fc899bfd36c",
      "arcName": "The Sequoia Pitch",
      "arcSlug": "sequoia-pitch",
      "beatName": "Product",
      "beatSlug": "sequoia-pitch-product",
      "evidence": "The 'MYBPC3 Gene Therapy Program', 'PKP2 Gene Therapy Program', and 'HDAC6i Small Molecule Program' slides",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": "Evidence",
      "parentBeatSlug": "evidence"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}