{
  "docId": "019de071-473e-712d-87f0-b99471a2308d",
  "docSlug": "b8bc6e04b9c70160cc1bc532a2ac4eea",
  "documentTitle": "Nuvalent | IPO Presentation Deck | 40 slides",
  "authorId": "nuvalent",
  "authorName": "Nuvalent",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investment_bank",
  "sourceTypeLabel": "Investment bank",
  "presentationDate": "2021-07-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7827299,
  "pageNumber": 20,
  "pageCount": 40,
  "prevPage": 19,
  "nextPage": 21,
  "slideType": "solution",
  "function": "present_solution",
  "density": "dense",
  "nDataPoints": 2,
  "notes": "The slide highlights CNS activity via brain penetration, a key component of the NVL-520 target product profile.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de071-473e-712d-87f0-b99471a2308d/20",
  "deckHref": "/decks/019de071-473e-712d-87f0-b99471a2308d",
  "deckJsonHref": "/decks/019de071-473e-712d-87f0-b99471a2308d.json",
  "deckAnchorHref": "/decks/019de071-473e-712d-87f0-b99471a2308d#slide-20",
  "components": [
    {
      "bbox": {
        "h": 0.45,
        "w": 0.35,
        "x": 0.42,
        "y": 0.33
      },
      "kind": "chart",
      "text": "Unbound brain:plasma ratio (Kp,uu) for NVL-520 vs Lorlatinib",
      "attrs": null,
      "subkind": "bar-vertical",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "f06b5f76-b3b6-4ac1-a68d-757799c90b95",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.08,
        "w": 0.75,
        "x": 0.225,
        "y": 0.88
      },
      "kind": "disclaimer",
      "text": "Experiments not powered to determine the statistical significance of differences in measurements between any of the inhibitors tested. No head-to-head clinical studies have been conducted for currently approved or investigational therapies versus NVL-520.",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "cccce315-b051-4a2f-b816-aee6eace186a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.5,
        "w": 0.18,
        "x": 0.02,
        "y": 0.25
      },
      "kind": "list",
      "text": "NVL-520 ROS1-selective Target Product Profile: Wild-type, Resistance mutations, TRK, Other off-targets, Brain penetration",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "0b6a3953-29ed-4ea1-a2bb-1dd8ea85f72e",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.15,
        "x": 0.25,
        "y": 0.32
      },
      "kind": "paragraph",
      "text": "in vivo Wistar Han rats Dose: 10 mg/kg QDx1 PO 1h timepoint",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8b3e8076-80b6-4752-abee-0245798dc09b",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.5,
        "x": 0.225,
        "y": 0.185
      },
      "kind": "title",
      "text": "Pharmacokinetic Data Similar to Preclinical Observations for Lorlatinib",
      "attrs": null,
      "subkind": "action-title",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9e8b900a-0c2b-4ea4-9e0f-5b319a5254a3",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.45,
        "x": 0.225,
        "y": 0.105
      },
      "kind": "title",
      "text": "Preclinical brain penetrance of NVL-520",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "62a33336-9859-4c77-953c-8d850cf351ea",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Waterfall chart",
      "slug": "waterfall-chart",
      "agent": null,
      "layer": "slide",
      "matchId": "365e74c4-5623-4d71-8294-609a46f19cdb",
      "evidence": "chart/bar-vertical: Unbound brain:plasma ratio (Kp,uu) for NVL-520 vs Lorlatinib",
      "confidence": 0.8
    }
  ],
  "frameworks": [],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}