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  "documentTitle": "Erasca | IPO Presentation Deck | 46 slides",
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  "authorName": "Erasca",
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  "presentationDate": "2021-07-01 00:00:00",
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  "notes": "The slide highlights the technical challenge of targeting the active GTP state and introduces specific programs (ERAS-4 and ERAS-2/3) to address this.",
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      "text": "Diagram showing RAS-GTP pathway and molecular structures of RAS-GDP vs RAS-GTP states",
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      "text": "Targeting KRAS G12D and other RAS-GTP mutations is more challenging, as they are more commonly found in the active GTP state. ERAS-4 KRAS G12D inhibitor program leverages expertise from ERAS-1 and ERAS-2/3 discovery. ERAS-2/3 RAS-GTP inhibitor program based on Kevan Shokat's identification of a new binding site called S-IIG that is present in both RAS-GTP and RAS-GDP states.",
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      "text": "Source: Gentile DR, et al., Cell Chem Biol. 2017 Dec 21;24(12):1455-1466.e14",
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      "text": "Beyond G12C: Targeting KRAS G12D and other RAS-GTP mutations",
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