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  "documentTitle": "Erasca | IPO Presentation Deck | 46 slides",
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  "presentationDate": "2021-07-01 00:00:00",
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  "notes": "The slide uses a scientific mechanism of action diagram to illustrate the inhibition of the GEF binding region.",
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      "text": "Mechanism of action diagram showing RAS-GDP/GTP cycle",
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      "text": "Structural biology diagrams showing inhibitor binding to S-II pocket",
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      "text": "Shokat identified a G12C-specific inhibitor that locks KRAS in inactive state. His discovery spurred multiple companies to develop KRAS G12C inhibitors. Efficacy to date has been modest and limited to NSCLC. High unmet need remains.",
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      "text": "Source: Ostrem J., et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 2013. PMID: 24256730",
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      "text": "Dr. Kevan Shokat at UCSF turned KRAS from undruggable to druggable",
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