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  "documentTitle": "Erasca | IPO Presentation Deck | 46 slides",
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  "authorName": "Erasca",
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  "presentationDate": "2021-07-01 00:00:00",
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  "notes": "The slide uses a biological pathway diagram to illustrate the position of ERK relative to other nodes like MEK and RAF.",
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      "text": "RAS/MAPK pathway diagram with ERK highlighted",
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      "text": "ERK1 and ERK2 are downstream components of a phospho-relay pathway that conveys growth and proliferation. As the most distal node of MAPK pathway, ERK is less susceptible to pathway reactivation compared to MEK. ERK activation is implicated in acquired resistance to RAFi/MEKi's and other targeted therapies. Opportunities exist for single agent and combination approaches.",
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