{
  "docId": "019de071-25c2-72af-a047-b47d3e86c276",
  "docSlug": "cf4915d9030a007285d7f2ca06f3bce1",
  "documentTitle": "Graphite Bio | IPO Presentation Deck | 50 slides",
  "authorId": "graphite-bio",
  "authorName": "Graphite Bio",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investment_bank",
  "sourceTypeLabel": "Investment bank",
  "presentationDate": "2021-06-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 25,
  "pageCount": 50,
  "prevPage": 24,
  "nextPage": 26,
  "slideType": "context",
  "function": "establish_context",
  "density": "balanced",
  "nDataPoints": 1,
  "notes": "The slide uses a scientific citation to validate the prevalence of the sickle trait.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de071-25c2-72af-a047-b47d3e86c276/25",
  "deckHref": "/decks/019de071-25c2-72af-a047-b47d3e86c276",
  "deckJsonHref": "/decks/019de071-25c2-72af-a047-b47d3e86c276.json",
  "deckAnchorHref": "/decks/019de071-25c2-72af-a047-b47d3e86c276#slide-25",
  "components": [
    {
      "bbox": {
        "h": 0.07,
        "w": 0.86,
        "x": 0.07,
        "y": 0.16
      },
      "kind": "callout",
      "text": ">100 million people live normal lives with sickle trait (one normal, one sickle gene)",
      "attrs": null,
      "subkind": "primary",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "0a7ba32e-a36a-40a7-b3df-7de08345d300",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.6,
        "w": 0.62,
        "x": 0.19,
        "y": 0.25
      },
      "kind": "image",
      "text": "Global heat map of HbS allele frequency",
      "attrs": null,
      "subkind": "map",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "7988dcd9-33fe-479b-b790-4bed843635d0",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.3,
        "x": 0.07,
        "y": 0.91
      },
      "kind": "source-note",
      "text": "Nature Communications. 1:104 doi: 10.1038/ncomms1104 (2010).",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "12cc3213-35be-4831-a909-17b25938111e",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.6,
        "x": 0.07,
        "y": 0.05
      },
      "kind": "title",
      "text": "Gene correction goal is to restore normal biology: Individuals with sickle trait are normal",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8adf3dac-accf-4b5c-8983-b81658fc3f97",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Contrast Pairs",
      "slug": "contrast-pairs",
      "agent": "Storyteller",
      "layer": "slide",
      "matchId": "0b333cc0-feee-4671-9bf7-c1e650182f55",
      "evidence": "callout/primary: >100 million people live normal lives with sickle trait (one normal, one sickle gene)",
      "confidence": 0.7
    }
  ],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 25,
      "from": 24,
      "beatId": "47bd7906-8a45-4c8f-8a98-d35865c81ceb",
      "arcName": "The Sparkline",
      "arcSlug": "sparkline",
      "beatName": "Problem (Identify pain)",
      "beatSlug": "problem-agitate-solution-problem-identify-pain",
      "evidence": "The problem statement (p24-25) highlights the need for curative therapy for sickle cell patients.",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": "Complication",
      "parentBeatSlug": "complication"
    }
  ],
  "loops": [
    {
      "to": 25,
      "from": 24,
      "name": "Cost Of Inaction",
      "slug": "27-cost-of-inaction",
      "bestFor": "Urgent budget requests, compliance, risk mitigation",
      "matchId": "4d05b716-3532-4b89-94c2-419df6b1eae9",
      "evidence": "The problem statement (p24-25) highlights the need for curative therapy.",
      "position": 2,
      "objective": "What is the cost of not having a curative therapy for sickle cell disease?",
      "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
      "confidence": 0.6,
      "description": "Quantify what happens if the audience does nothing"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}