{
  "docId": "019de071-1981-7442-94ed-ee285d10f59b",
  "docSlug": "c18efbd116f640ca1060cd96d0c18250",
  "documentTitle": "Alkermes | Results Presentation Deck | 31 slides",
  "authorId": "alkermes",
  "authorName": "Alkermes",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2021-06-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 28,
  "pageCount": 31,
  "prevPage": 27,
  "nextPage": 29,
  "slideType": "executive_summary",
  "function": "summarize",
  "density": "dense",
  "nDataPoints": 6,
  "notes": null,
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de071-1981-7442-94ed-ee285d10f59b/28",
  "deckHref": "/decks/019de071-1981-7442-94ed-ee285d10f59b",
  "deckJsonHref": "/decks/019de071-1981-7442-94ed-ee285d10f59b.json",
  "deckAnchorHref": "/decks/019de071-1981-7442-94ed-ee285d10f59b#slide-28",
  "components": [
    {
      "bbox": {
        "h": 0.15,
        "w": 0.9,
        "x": 0.056,
        "y": 0.45
      },
      "kind": "list",
      "text": "Of 57 patients treated with SC nemvaleukin during dose escalation (phase 1), 31 had stable disease on first scan. Of 37 patients with ≥ 2 on-treatment scans, 17 had stable disease on two or more consecutive scans.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "49f3569e-958e-499b-b7de-e4b16fb842b5",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.6,
        "x": 0.056,
        "y": 0.7
      },
      "kind": "list",
      "text": "In phase 2 expansion stage: 1 PR has been observed in a patient with PROC",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "4de6e927-13a4-4dab-84f4-6cc7564bca8f",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.88,
        "x": 0.056,
        "y": 0.275
      },
      "kind": "list",
      "text": "SC nemvaleukin selectively increased CD8+ T and NK cells, with low-level, transient, non-dose-dependent expansion of Tregs. These effects were similar to or greater than those observed with IV nemvaleukin.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a976d9cd-b596-44f0-a894-ec562d9830be",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.85,
        "x": 0.056,
        "y": 0.585
      },
      "kind": "list",
      "text": "Phase 2 tumor-specific expansion cohorts at SC nemvaleukin RP2D of 3 mg q7d in combination with pembrolizumab have started enrolling.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ada709d4-764b-44c2-a3d2-26971701629c",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.083,
        "w": 0.433,
        "x": 0.056,
        "y": 0.125
      },
      "kind": "title",
      "text": "ARTISTRY-2 Data Summary",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "6add7425-9436-48f6-a56f-a6f6a2094e85",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Executive summary",
      "slug": "executive-summary",
      "agent": null,
      "layer": "slide",
      "matchId": "760973bc-1900-4baa-bd15-b95ac94c4c42",
      "evidence": "The slide provides a concise summary of the ARTISTRY-2 data, highlighting key findings.",
      "confidence": 0.9
    }
  ],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 31,
      "from": 22,
      "beatId": "6729dbcf-9af8-4183-a612-b8bbf1c1b0a8",
      "arcName": "The Consultant's Gambit",
      "arcSlug": "consultants-gambit",
      "beatName": "Impact & Next Steps",
      "beatSlug": "consultants-gambit-impact-next-steps",
      "evidence": "The presentation concludes with a summary of results and a panel discussion",
      "position": 3,
      "confidence": 0.8,
      "parentBeatName": "Resolution",
      "parentBeatSlug": "resolution"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}