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      "text": "Introduction to synaptogenesis and synaptic dysfunction\nBiological rationale for the program:\n- Established epigenetic control of synapse formation and function modulated by HDAC inhibitors\n- Limitations of first-generation HDAC agents as CNS therapeutics\nAlkermes' novel chemotypes: Rationally designed to selectively target the HDAC1/2 CoREST complex\nALKS 1140: First nominated development candidate from HDAC inhibitor portfolio\nLeveraging proprietary chemistry and insight to other potential compounds and indications, including Frontotemporal Dementia with Granulin Precursor Mutations (FTD-GRN)",
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