{
  "docId": "019de070-8dac-72dd-8b30-47dcdd26ea78",
  "docSlug": "14b2a339e11f22ed5b817a794c035302",
  "documentTitle": "Chimerix | Mergers and Acquisitions Presentation Deck | 26 slides",
  "authorId": "chimerix",
  "authorName": "Chimerix",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investment_bank",
  "sourceTypeLabel": "Investment bank",
  "presentationDate": "2021-01-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 13,
  "pageCount": 26,
  "prevPage": 12,
  "nextPage": 14,
  "slideType": "other",
  "function": "present_framework",
  "density": "dense",
  "nDataPoints": 0,
  "notes": "Includes a BioRender diagram illustrating the molecular pathway.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de070-8dac-72dd-8b30-47dcdd26ea78/13",
  "deckHref": "/decks/019de070-8dac-72dd-8b30-47dcdd26ea78",
  "deckJsonHref": "/decks/019de070-8dac-72dd-8b30-47dcdd26ea78.json",
  "deckAnchorHref": "/decks/019de070-8dac-72dd-8b30-47dcdd26ea78#slide-13",
  "components": [
    {
      "bbox": {
        "h": 0.7,
        "w": 0.5,
        "x": 0.03,
        "y": 0.2
      },
      "kind": "image",
      "text": "Mechanism of action diagram",
      "attrs": null,
      "subkind": "infographic",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "e678c8ab-556c-4c1b-9cdc-03d73d29571d",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.7,
        "w": 0.42,
        "x": 0.55,
        "y": 0.18
      },
      "kind": "list",
      "text": "ONC201 can selectively induce apoptosis in cancer cells by altering activity of two proteins. ClpP agonism: ClpP normally degrades misfolded proteins in mitochondria; ONC201 modifies ClpP conformation. DRD2 antagonism: DRD2 is a G protein-coupled neuroreceptor.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ecb932aa-7d5f-4449-a6a7-abb19c24e86d",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.65,
        "x": 0.03,
        "y": 0.93
      },
      "kind": "source-note",
      "text": "ClpP=caseinolytic protease P; DRD2=Dopamine receptor D2; ATF4=activating transcription factor 4; CHOP=C/EBP-homologous protein; ERK=extracellular-regulated kinase; AKT=protein kinase B",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3c07e99e-50e3-4ca8-9578-cd19fccc1a90",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.95,
        "x": 0.03,
        "y": 0.1
      },
      "kind": "title",
      "text": "ONC201 upregulates integrated stress response, inactivates Akt/ERK, selectively inducing tumor cell death",
      "attrs": null,
      "subkind": "action-title",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3650f8f7-f6bc-4e4a-b106-d2e9138b5179",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.08,
        "w": 0.45,
        "x": 0.03,
        "y": 0.03
      },
      "kind": "title",
      "text": "ONC201 targets ClpP and DRD2",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a3f4d49c-a040-451e-94e5-f11a9654abca",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}