{
  "docId": "019de070-5bad-7209-9a4b-c2388bb12878",
  "docSlug": "45a794600ccc29f3eaf009a5452211e7",
  "documentTitle": "Codiak | IPO Presentation Deck | 36 slides",
  "authorId": "codiak",
  "authorName": "Codiak",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investment_bank",
  "sourceTypeLabel": "Investment bank",
  "presentationDate": "2020-10-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 25,
  "pageCount": 36,
  "prevPage": 24,
  "nextPage": 26,
  "slideType": "solution",
  "function": "present_solution",
  "density": "dense",
  "nDataPoints": 0,
  "notes": "The slide highlights the mechanism of action (M2 to M1 repolarization) and key design elements including preclinical efficacy and delivery routes.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de070-5bad-7209-9a4b-c2388bb12878/25",
  "deckHref": "/decks/019de070-5bad-7209-9a4b-c2388bb12878",
  "deckJsonHref": "/decks/019de070-5bad-7209-9a4b-c2388bb12878.json",
  "deckAnchorHref": "/decks/019de070-5bad-7209-9a4b-c2388bb12878#slide-25",
  "components": [
    {
      "bbox": {
        "h": 0.08,
        "w": 0.4,
        "x": 0.3,
        "y": 0.88
      },
      "kind": "callout",
      "text": "IND filing anticipated H2 2021",
      "attrs": null,
      "subkind": "primary",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c48154ee-22c1-4c0b-b66c-424557d4cb76",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.9,
        "x": 0.05,
        "y": 0.65
      },
      "kind": "framework",
      "text": "KEY DESIGN ELEMENTS/OBSERVATIONS: Selective delivery to M2 macrophages; Single-agent complete anti-tumor response in preclinical models; Broad therapeutic index with multiple routes of administration",
      "attrs": null,
      "subkind": "instance",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "d0b297fe-8e6a-4847-adb8-e460af301a85",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.4,
        "w": 0.3,
        "x": 0.35,
        "y": 0.2
      },
      "kind": "image",
      "text": "Diagram of exosome with STAT-6 ASO and PTGFRN",
      "attrs": null,
      "subkind": "illustration",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "f130db1c-c2e1-46ff-8ea3-e0840bc0cbda",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.3,
        "x": 0.65,
        "y": 0.25
      },
      "kind": "list",
      "text": "Cell selective transcription factor regulation; Enhanced therapeutic index; TME selective delivery",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "5df4c903-3c3b-4568-987c-3a105e0ce897",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.3,
        "x": 0.05,
        "y": 0.22
      },
      "kind": "paragraph",
      "text": "Mechanism of Action: IT/Systemic Injection -> M2 macrophage selective uptake M2 to M1 Repolarization",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "7403edea-b6bd-41c1-bb0f-4bdd477fe9c2",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.9,
        "x": 0.03,
        "y": 0.05
      },
      "kind": "title",
      "text": "exoASO-STAT6: Selective Knockdown of STAT-6 Transcription Factor Repolarizes M2 Macrophages in the TME",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "fba5eeca-1adf-4c98-87fe-ec27d90325a5",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 35,
      "from": 16,
      "beatId": "87a4caff-9c60-44c7-b0ac-0079e1a8e9eb",
      "arcName": "The Sequoia Pitch",
      "arcSlug": "sequoia-pitch",
      "beatName": "Roadmap",
      "beatSlug": null,
      "evidence": "Slides 16-35 outline Codiak's pipeline, clinical programs, and future plans",
      "position": 3,
      "confidence": 0.8,
      "parentBeatName": null,
      "parentBeatSlug": null
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}