{
  "docId": "019de070-5095-745c-b54c-b78e5ae1b904",
  "docSlug": "0dc8a543e5d2136d106b59f85712c2a9",
  "documentTitle": "Taysha | IPO Presentation Deck | 66 slides",
  "authorId": "taysha",
  "authorName": "Taysha Gene Therapies",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investment_bank",
  "sourceTypeLabel": "Investment bank",
  "presentationDate": "2020-09-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 29,
  "pageCount": 66,
  "prevPage": 28,
  "nextPage": 30,
  "slideType": "problem_statement",
  "function": "frame_problem",
  "density": "balanced",
  "nDataPoints": 0,
  "notes": "Includes a visual spectrum diagram showing the relationship between MECP2 expression levels and clinical outcomes.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de070-5095-745c-b54c-b78e5ae1b904/29",
  "deckHref": "/decks/019de070-5095-745c-b54c-b78e5ae1b904",
  "deckJsonHref": "/decks/019de070-5095-745c-b54c-b78e5ae1b904.json",
  "deckAnchorHref": "/decks/019de070-5095-745c-b54c-b78e5ae1b904#slide-29",
  "components": [
    {
      "bbox": {
        "h": 0.5,
        "w": 0.4,
        "x": 0.55,
        "y": 0.3
      },
      "kind": "image",
      "text": "Diagram showing cell clusters with varying levels of WT (wild-type) MECP2 and a spectrum bar below ranging from loss to overexpression.",
      "attrs": null,
      "subkind": "illustration",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "57e74c45-7a3c-4122-88a4-2ca2738371b2",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.5,
        "w": 0.45,
        "x": 0.05,
        "y": 0.25
      },
      "kind": "list",
      "text": "Characterized by mutations in methyl CpG-binding protein 2 (MeCP2), a protein that is essential for neuronal and synaptic function in the brain. Female heterozygous RTT patients are mosaic carriers of normal and mutated MECP2. RTT falls along a spectrum of MeCP2 activity and toxicity from gene therapies is linked to unregulated expression of MECP2. MECP2 expression must be regulated to correct the deficiency, while avoiding toxicity associated with overexpression",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "033d663e-3c79-4db7-b364-c2ac8ab9e4f1",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.45,
        "x": 0.05,
        "y": 0.05
      },
      "kind": "title",
      "text": "Rett syndrome (RTT) is an X-linked neurodevelopmental disorder",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a6544adc-61d7-49ed-87c2-45f643bd8867",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Problem Statement Canvas",
      "slug": "problem-statement-canvas",
      "agent": "Architect",
      "layer": "slide",
      "matchId": "fb965d51-fd76-4b17-be16-ae3e3effb13c",
      "evidence": "Characterized by mutations in methyl CpG-binding protein 2 (MeCP2), a protein that is essential for neuronal and synaptic function in the brain.",
      "confidence": 0.7
    }
  ],
  "frameworks": [
    {
      "name": "spectrum-analysis",
      "slug": null,
      "matchId": "66833ee7-6270-4895-8594-19a7dd73bccd",
      "evidence": "The slide uses a linear spectrum to define the therapeutic window for MECP2 expression.",
      "confidence": 0.8
    }
  ],
  "arcBeats": [
    {
      "to": 30,
      "from": 16,
      "beatId": "92c49c1c-860e-455e-833b-2b3bc63c64c4",
      "arcName": "AIDA",
      "arcSlug": "aida",
      "beatName": "Desire",
      "beatSlug": "aida-desire",
      "evidence": "The deck presents the problem statements, context, and solution for various neurodegenerative and neurodevelopmental disorders, creating a desire for a solution.",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": "Evidence",
      "parentBeatSlug": "evidence"
    }
  ],
  "loops": [
    {
      "to": 36,
      "from": 28,
      "name": "Aha Moment",
      "slug": "03-aha-moment",
      "bestFor": "Data-heavy sections, research findings, analytical arguments",
      "matchId": "b03fcf84-5a66-46c7-b35a-c62163b814de",
      "evidence": "The deck presents a clear aha moment, highlighting the importance of regulated expression of MECP2.",
      "position": 1,
      "objective": "Understand the need for regulated expression of MECP2 in Rett syndrome",
      "structure": "The Problem/Question -> What the Data Shows -> The Insight",
      "confidence": 0.7,
      "description": "Establish a tension, present data, then deliver the insight that changes everything"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}