{
  "docId": "019de070-3f4a-73d8-b295-3b15c76ba522",
  "docSlug": "bc1fcb576f82bf5c3541f439604f314c",
  "documentTitle": "Kymera | IPO Presentation Deck | 49 slides",
  "authorId": "kymera",
  "authorName": "Kymera",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investment_bank",
  "sourceTypeLabel": "Investment bank",
  "presentationDate": "2020-08-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 36,
  "pageCount": 49,
  "prevPage": 35,
  "nextPage": 37,
  "slideType": "why_now",
  "function": "present_solution",
  "density": "dense",
  "nDataPoints": 0,
  "notes": "The slide uses a biological pathway diagram to illustrate the JAK-STAT signaling mechanism.",
  "elementsJson": null,
  "metadataConfidence": 0.95,
  "imagePath": null,
  "slideHref": "/slides/019de070-3f4a-73d8-b295-3b15c76ba522/36",
  "deckHref": "/decks/019de070-3f4a-73d8-b295-3b15c76ba522",
  "deckJsonHref": "/decks/019de070-3f4a-73d8-b295-3b15c76ba522.json",
  "deckAnchorHref": "/decks/019de070-3f4a-73d8-b295-3b15c76ba522#slide-36",
  "components": [
    {
      "bbox": {
        "h": 0.65,
        "w": 0.45,
        "x": 0.52,
        "y": 0.2
      },
      "kind": "image",
      "text": "Biological pathway diagram showing IL-6/JAK/STAT signaling",
      "attrs": null,
      "subkind": "illustration",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "354c83cf-a02d-4c25-90e5-215782a73e48",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.45,
        "w": 0.45,
        "x": 0.05,
        "y": 0.2
      },
      "kind": "list",
      "text": "STAT3 is a traditionally largely undrugged transcription factor activated through cytokine and growth factor receptors via JAKs and non-JAKs mediated mechanisms. High degree of validation of JAK-STAT pathway in oncology and immuno-oncology supported also by numerous publications. STAT3 plays a role in tumor biology, evasion of immune surveillance and inflammation/fibrosis. No known drugs specifically affect STAT3 broadly across all relevant cell types. First in class opportunity to address STAT3 driven pathology across large and diverse indications.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8b4ad72c-d0ab-4fd0-aab6-cf1b649de5bd",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.45,
        "x": 0.05,
        "y": 0.7
      },
      "kind": "table",
      "text": "Indications/Timeline: Hematological Malignancies/Solid Tumors and Autoimmune/Fibrosis. Current: Preclinical development. Expected IND submission: 2H 2021. Expected P1: 2H21",
      "attrs": null,
      "subkind": "data",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "74541c05-1073-4deb-baca-95a1612532f4",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.5,
        "x": 0.25,
        "y": 0.05
      },
      "kind": "title",
      "text": "STAT3 Biology and Degrader Rationale",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9c3c6030-1528-4c27-bf8e-0cd362dd04d5",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}