{
  "docId": "019de070-3f4a-73d8-b295-3b15c76ba522",
  "docSlug": "bc1fcb576f82bf5c3541f439604f314c",
  "documentTitle": "Kymera | IPO Presentation Deck | 49 slides",
  "authorId": "kymera",
  "authorName": "Kymera",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investment_bank",
  "sourceTypeLabel": "Investment bank",
  "presentationDate": "2020-08-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 32,
  "pageCount": 49,
  "prevPage": 31,
  "nextPage": 33,
  "slideType": "solution",
  "function": "present_solution",
  "density": "balanced",
  "nDataPoints": 10,
  "notes": "The table shows IC50 values for various cell lines, highlighting significantly lower values (higher potency) for MYD88-mutant lines compared to wild-type.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de070-3f4a-73d8-b295-3b15c76ba522/32",
  "deckHref": "/decks/019de070-3f4a-73d8-b295-3b15c76ba522",
  "deckJsonHref": "/decks/019de070-3f4a-73d8-b295-3b15c76ba522.json",
  "deckAnchorHref": "/decks/019de070-3f4a-73d8-b295-3b15c76ba522#slide-32",
  "components": [
    {
      "bbox": {
        "h": 0.45,
        "w": 0.25,
        "x": 0.06,
        "y": 0.28
      },
      "kind": "paragraph",
      "text": "Lead IRAKIMiD degrader is a selective and efficient degrader of both IRAK4 and the IMiD substrates. IRAK4 DC50 = 8 nM. Ikaros/Aiolos DC50 = 2 nM. Degradation leads to cell viability effects preferentially in MYD88-mutant lines irrespective of other mutational status. Data support potential for broadly targeting tumors harboring MYD88 mutations.",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c3604401-d603-4f1b-b0ea-f9f3039d05a6",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.55,
        "w": 0.58,
        "x": 0.35,
        "y": 0.28
      },
      "kind": "table",
      "text": "Model, MYD88, CD79A/B, TNFAIP3, IRF4, BCL6, IRAKIMiD (IC50 uM). OCI-LY10, L265P mut, mut, 0.008. TMD8, L265P mut, mut, mut, 0.022. SUDHL-2, S222R mut, mut, mut, mut, 0.013. OCI-LY19, Wild type, mut, 3.6. U2932, Wild type, 2.3.",
      "attrs": null,
      "subkind": "data",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ef55b91e-abcd-4617-ac41-34f9a67de0a8",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.08,
        "w": 0.56,
        "x": 0.22,
        "y": 0.05
      },
      "kind": "title",
      "text": "Lead IRAKIMiD Selective for MYD88 Tumors Irrespective of Co-mutations",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "49a7d15e-3a9c-4c9c-b4d3-a66ffb3aaf36",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Table data",
      "slug": "table-data",
      "agent": null,
      "layer": "slide",
      "matchId": "4b905940-24c9-4877-bbbb-a9737be809ab",
      "evidence": "table/data: Model, MYD88, CD79A/B, TNFAIP3, IRF4, BCL6, IRAKIMiD (IC50 uM).",
      "confidence": 0.9
    }
  ],
  "frameworks": [],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}