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      "text": "Pathway diagram showing IRAK4 degrader and IMiDs mechanism of action on B cell receptor signaling pathways.",
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      "text": "MYD88 mutation drives differentiation and proliferation in subset of B cell lymphomas. Selective kinase inhibitors do not affect viability. Degraders are effective in this context. IMiDs downregulate IRF4, increasing IFN signaling and further suppressing NFkB activation. Inhibiting both MYD88 and IRF4-dependent NFkB and activating IFN signaling drive cell death in MYD88-mutant lymphomas and leads to full and durable responses in vivo.",
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