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      "text": "Ability to inhibit topical skin thickening induced by imiquimod was measured in a mouse model of psoriasis. Orally dosed KT-474 inhibited thickening, a reflection of local and systemic inflammation, comparable to a topic corticosteroid after 2 or 4 days of dosing. Inhibition shown at doses achieving at least 60-70% IRAK4 knockdown in skin and spleen",
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