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  "documentTitle": "Kymera | IPO Presentation Deck | 49 slides",
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  "authorName": "Kymera",
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  "presentationDate": "2020-08-01 00:00:00",
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  "notes": "Includes a diagram showing the mechanism of action for an IRAK4 degrader versus a kinase inhibitor.",
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      "text": "Mechanism of action diagram showing IRAK4 kinase-dependent and independent pathways and the impact of IRAK4 degraders vs kinase inhibitors.",
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      "text": "IRAK4 is a key component of myddosome protein complex; Myddosome involved in innate immunity that mediates signals through IL-1R and TLRs; IL-1R/TLR signaling through the myddosome complex is dependent on IRAK4 kinase and scaffolding functions; Degrading IRAK4 we believe can provide a single oral small molecule solution to many diseases impacted by this pathway",
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      "text": "Indications/Timeline: AD, Hidradenitis Suppurativa (HS), RA; Current: IND enabling studies; Expected IND submission: 1H 2021; Expected P1: 1H 2021",
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      "text": "IRAK4 Biology and Degrader Rationale",
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