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  "documentTitle": "Aeglea BioTherapeutics | Investor Presentation Deck | 28 slides",
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  "presentationDate": "2020-08-01 00:00:00",
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  "notes": "Includes a visual demonstration of spastic diplegia in a patient.",
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      "text": "1. Aeglea Data on File 2. Huemer M, et al. J Inherit Metab Dis. 2016;39:331-340 3.Burrage LC, et al. Hum Mol Genet. 2015;24:6417-6427 4. Carvalho DR, et al. Pediatr Neurol. 2012;46:369-374 5.Haberle J et al J Inherit Metab Dis, 2019, 6.Diez-Fernandez C, et al. Hum Mutat. 2018;39:1029-1050, 7.Carvalho DR et al. Gene 2012; 509(1): 124-130.",
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      "text": "Prominent and progressive neurological manifestations; Impaired mobility due to characteristic spastic diplegia; Seizures are a common feature",
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      "text": "Typically presents at ~2-4 years of age, can be later; Developmental delay with increasing intellectual disability; Failure to thrive and short stature",
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      "text": "Additional abnormalities due to impairment urea cycle; Hyperammonemia but less prominent than other urea cycle disorders; Protein aversion, food refusal and self-restriction of protein",
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      "kind": "title",
      "text": "Arginase 1 Deficiency (ARG1-D)",
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