{
  "docId": "019de070-3a76-76eb-bdcd-70a194f2629a",
  "docSlug": "3b5651eafaa236908b5aaeea5fdc2dcc",
  "documentTitle": "Aeglea BioTherapeutics | Investor Presentation Deck | 28 slides",
  "authorId": "aeglea-biotherapeutics",
  "authorName": "Aeglea BioTherapeutics",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2020-08-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 20,
  "pageCount": 28,
  "prevPage": 19,
  "nextPage": 21,
  "slideType": "problem_statement",
  "function": "frame_problem",
  "density": "dense",
  "nDataPoints": 10,
  "notes": "The slide uses a Kaplan-Meier survival curve and a comparative table to illustrate the severity of the disease.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de070-3a76-76eb-bdcd-70a194f2629a/20",
  "deckHref": "/decks/019de070-3a76-76eb-bdcd-70a194f2629a",
  "deckJsonHref": "/decks/019de070-3a76-76eb-bdcd-70a194f2629a.json",
  "deckAnchorHref": "/decks/019de070-3a76-76eb-bdcd-70a194f2629a#slide-20",
  "components": [
    {
      "bbox": {
        "h": 0.45,
        "w": 0.4,
        "x": 0.05,
        "y": 0.38
      },
      "kind": "chart",
      "text": "Natural History Study of Untreated CBS Deficient Patients (Kaplan-Meier survival curve)",
      "attrs": null,
      "subkind": "line",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "b2b073b0-8f94-41fa-850e-4c94e440b8a3",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.04,
        "w": 0.4,
        "x": 0.27,
        "y": 0.93
      },
      "kind": "source-note",
      "text": "Mudd et al, 1985; Kluiitmans et al, Am. J. Hum. Genet. 65,59-67, 1999, CBS – Cystathionine β-synthase",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a58aa6d5-21a3-4648-bef7-e5a265383e80",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.06,
        "w": 0.8,
        "x": 0.04,
        "y": 0.19
      },
      "kind": "subtitle",
      "text": "Complication risk is dependent on severity of metabolic defect (B6 responsive vs non-responsive) and homocysteine levels",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "2b5b8cd0-f061-429a-94a8-f98a4f332740",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.42,
        "w": 0.48,
        "x": 0.47,
        "y": 0.41
      },
      "kind": "table",
      "text": "Comparison table of B6-non-responsive vs B6-responsive patients across various clinical metrics.",
      "attrs": null,
      "subkind": "data",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "4a45efad-da53-4063-b4e3-35f0e8187f66",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.9,
        "x": 0.04,
        "y": 0.07
      },
      "kind": "title",
      "text": "Increased Mortality and Severe Complication Risk in Patients with Homocystinuria",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "b232c1c8-f4cd-45b1-bfb6-185884320434",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "evidence-matrix",
      "slug": null,
      "matchId": "5bd7952a-579f-49f6-a335-832ad3d87939",
      "evidence": "Comparison of clinical outcomes between two patient cohorts",
      "confidence": 0.8
    }
  ],
  "arcBeats": [],
  "loops": [
    {
      "to": 21,
      "from": 20,
      "name": "Cost Of Inaction",
      "slug": "27-cost-of-inaction",
      "bestFor": "Urgent budget requests, compliance, risk mitigation",
      "matchId": "27135307-336f-47bb-8e99-a1794510d33f",
      "evidence": "Slides 20-21 present the increased mortality and severe complication risk in patients with Homocystinuria",
      "position": 0,
      "objective": "Highlighting the consequences of not addressing Homocystinuria",
      "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
      "confidence": 0.7,
      "description": "Quantify what happens if the audience does nothing"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}