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  "documentTitle": "Calliditas Therapeutics | IPO Presentation Deck | 38 slides",
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  "notes": "The slide uses a bulleted list to explain the pathophysiology of PBC and AIH.",
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      "text": "Autoimmune liver diseases originate from the liver. The autoimmune process is believed to be initiated by antigen-induced production of cytotoxic T-cells and B-cell derived auto-antibodies. In PBC, the cytotoxic T-cells and the auto-antibodies are directed towards antigens on the surface of the epithelial cells of the small bile ducts in the liver, resulting in inflammation and damage to the duct cells and eventually destroying the bile ducts. The destruction of bile ducts result in an increase of bile to levels that are toxic to the liver cells, eventually resulting in liver impairment, cirrhosis and ESLD. In AIH, the cytotoxic T-cells and auto-antibodies are directed towards antigens presented on the surface of the liver cells, leading to liver impairment, cirrhosis and eventually ESLD.",
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      "text": "Source: 1) Hirshfield, 2013, Annu Rev Pathol, 8:303-30; 2) Manns, Journal of Hepatology 2015, 62:S100-S111",
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      "text": "Opportunity for disease modifying treatment of autoimmune liver diseases",
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