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  "documentTitle": "ATAI | Investor Presentation Deck | 49 slides",
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  "authorName": "atai Life Sciences",
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  "presentationDate": "2020-06-01 00:00:00",
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  "notes": "CADSS = Clinician Administered Dissociative States Scale. Data points are plotted over time (Baseline, 15m, 40m, 90m).",
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      "text": "CADSS scores over time for PCN-101 30mg, 60mg, and Placebo",
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      "text": "PCN-101 30mg (n=6), PCN-101 60mg (n=6), Placebo (n=12)",
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      "text": "The Phase 1 data in healthy volunteers showed that PCN-101 was well tolerated at all doses up to 150 mg. Importantly, the onset of dissociative and psychotomimetic effects was observed to occur at fourfold higher doses than the equimolar doses of S-ketamine (i.e. CADSS scores ranging from 12-15). Based on the results, we have decided to test a 30mg and 60mg dose in the upcoming Phase 2 proof-of-concept trial. The associated CADDS score with these doses suggest at-home administration of PCN-101 could be feasible (versus in-clinic administration of S-ketamine). Dissociative compounds such as GHB have been commercialized by Jazz Pharmaceuticals under the Xyrem & Xywav brands",
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      "text": "(1) Phase 1 data presented at 4th Annual Neuropsychiatric Drug Development Summit (Sept 29th - 30th 2021)",
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      "text": "PCN-101 Phase 1 data: 30 & 60 mg dosing showed minimal to no dissociation (presented at NPDD summit¹)",
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