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  "documentTitle": "Aeglea BioTherapeutics | Results Presentation Deck | 13 slides",
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  "authorName": "Aeglea BioTherapeutics",
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  "presentationDate": "2020-05-01 00:00:00",
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  "notes": "Includes before/after photos of the patient demonstrating improved mobility.",
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      "text": "Patient 5: Baseline",
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      "text": "Patient 5: 20 Week Analysis",
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      "text": "Teenage girl diagnosed at age 1 (presented with hyperammonaemia)\nDeveloped severe lower limb spasticity, speech delay, intellectual disability\nTreated with severe protein restriction, essential amino acids, and ammonia scavengers\nPersistent hyperargininaemia\nProgressive worsening of lower extremity diplegia, walked with arm crutches at baseline (GMFCS II)",
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      "text": "* Achieved MCID: 6MWT = 16m; GMFM-D = 3.3; GMFM-E = 2.8",
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      "kind": "source-note",
      "text": "Images by kind permission of Dr GA Diaz",
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      "text": "Assessment, Normal Population, Baseline, 20 Week Analysis, 56 Week Analysis; Plasma arginine, 40-115uM, 363uM, 108.5uM, 88.2uM; 6MWT, 310-664m, 174m, 176m, 209m; GMFM-D, Max=39, 21, 27, 28; GMFM-E, Max=72, 27, 35, 34",
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      "kind": "title",
      "text": "Clinically Impactful Improvements at Patient Level with Pegzilarginase",
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