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      "text": "Even with strict dietary restriction, plasma arginine levels ≤200 µM are very difficult to achieve. Diet-related reductions in plasma arginine are not always accompanied by consistent reductions in guanidino compound levels. Current dietary strategies and use of ammonia scavengers are unable to fully alter disease progression and improve clinical status of patients.",
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      "text": "1. Burrage LC, et al. Hum Mol Genet. 2015;24:6417–6427; 2. Huemer M, et al. J Inherit Metab Dis. 2016;39:331–340; 3. Diez-Fernandez C, et al. Hum Mutat. 2018;39:1029–1050; 4. Marescau B, et al. Pediatr Res. 1990;27:297–303; 5. Amayreh W, et al. Dev Med Child Neurol. 2014;56:1021–1024; 6. Uchino T, et al. Hum Genet. 1995;96:255–260.",
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