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  "documentTitle": "Accelerate Diagnostics (AXDX)",
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  "presentationDate": "2019-09-16 00:00:00",
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  "notes": "The slide uses a rhetorical question to challenge the value proposition of rapid diagnostics in the context of standard sepsis care protocols.",
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      "text": "So data rarely changes the management.",
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      "text": "Measure lactate level.\nObtain blood cultures prior to administration of antibiotics\nAdminister broad-spectrum antibiotics\nRapidly administer 30 mL/kg crystalloid for hypotension or lactate ≥ 4 mmol/L\nApply vasopressors if patient is hypotensive during or after fluid resuscitation to maintain mean arterial pressure",
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      "text": "Here is a very interesting observation about the value of AST testing, expressed by a renown expert, Dr. Christopher D. Doern from Virginia Commonwealth University Health System. He expressed his opinion, when writing an editorial note on the Pheno system investigation paper.",
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      "text": "We looked at the clinical guidance for sepsis management and found no mention of the importance of rapid ID or AST testing. From analyzing the influential Surviving Sepsis Campaign, the most critical aspect of sepsis management is to treat it as a medical emergency and perform a bundle of specific actions within the first hour of sepsis signs, which are:",
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      "text": "information help you to change the patient infection management whether you know or do not know what pathogen it is? Then the answer is it’s a very small percentage, because in most cases, if patients are sick enough, they will be placed on board spectrum antibiotics. So data rarely changes the management.",
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      "text": "The IDSA (Infection Diseases Society of America) Guide for utilization of the Microbiology Lab does not provide any recommendation on using rapid diagnostics. Instead, in its chapter on bloodstream infection it mainly discusses blood sample collection and transportation to minimize contamination and how to improve success with the cell culture test.",
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      "text": "Copyright 2019 White Diamond Research research@whitediamondresearch.com",
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