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  "documentTitle": "PMV Pharmaceuticals (PMVP)",
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  "presentationDate": "2022-05-19 00:00:00",
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  "notes": "The slide uses a combination of scientific critique (gel analysis) and quantitative data (bar chart) to challenge the validity of the company's preclinical findings.",
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      "text": "However, as we can see below, the results that PMV shared in their latest 10-K8 did not line up, suggesting that they are not the same protein.",
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      "text": "p53 Levels Across Cell Lines (Total p53 ELISA)",
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      "text": "Gel electrophoresis image showing p53 and Actin levels",
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      "text": "To do this experiment, we believe researchers had to run two gels – one with protein immunoprecipitated with an antibody specific for mutant p53 and another with an antibody specific for wild-type p53.",
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      "text": "If the Y220c p53 mutated protein is different in different cell lines, then preclinical data showing response in various cell lines become less convincing of efficacy translating to humans.",
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      "text": "8 PMV, 10-K, 10, 3/1/2022",
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