{
  "docId": "019dd923-622c-750b-8b9a-8c03a48e7d6f",
  "docSlug": "86e21d9d1e23",
  "documentTitle": "PMV Pharmaceuticals (PMVP)",
  "authorId": "60_Wolfpack_Research",
  "authorName": "Wolfpack Research",
  "documentKindSlug": "research-note",
  "documentKindLabel": "Research note",
  "sourceTypeSlug": "short_seller",
  "sourceTypeLabel": "Short seller",
  "presentationDate": "2022-05-19 00:00:00",
  "orientation": "portrait",
  "aspectRatio": 0.77272725,
  "pageNumber": 4,
  "pageCount": 19,
  "prevPage": 3,
  "nextPage": 5,
  "slideType": "expose_contradiction",
  "function": "expose_contradiction",
  "density": "balanced",
  "nDataPoints": 0,
  "notes": "The slide includes a visual critique of a Western blot image, highlighting misaligned wells as evidence of image manipulation.",
  "elementsJson": [
    "paragraph",
    "screenshot",
    "callout_box"
  ],
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019dd923-622c-750b-8b9a-8c03a48e7d6f/4",
  "deckHref": "/decks/019dd923-622c-750b-8b9a-8c03a48e7d6f",
  "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-8c03a48e7d6f.json",
  "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-8c03a48e7d6f#slide-4",
  "components": [
    {
      "bbox": null,
      "kind": "callout",
      "text": "PC14586 induces conversion of p53 protein from mutant to wild-type conformation in a dose-dependent manner, as evidence by a decrease in mutant p53, increase in wild-type p53 and relatively unchanged level of total p53",
      "attrs": null,
      "subkind": null,
      "toolName": "Visual emphasis",
      "toolSlug": "visual-emphasis",
      "confidence": null,
      "componentId": "019dd953-70f9-71ae-a678-1b609435ab01",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.65,
        "x": 0.18,
        "y": 0.39
      },
      "kind": "image",
      "text": "Western blot image showing PC14586 structural conversion with blue box highlighting misalignment",
      "attrs": null,
      "subkind": "screenshot",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c0a857ed-7479-476f-a5b6-cfa2113b98e9",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.08,
        "w": 0.8,
        "x": 0.11,
        "y": 0.69
      },
      "kind": "paragraph",
      "text": "This picture is designed to show the mechanistic concept of the structural conversion... However, it appears this was photoshopped to demonstrate the concept of the drug (note the blue box we drew to show the wells are not aligned).",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "089e83f9-f5cd-4276-960d-537802e74782",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.08,
        "w": 0.8,
        "x": 0.11,
        "y": 0.09
      },
      "kind": "paragraph",
      "text": "PMV calls PC14586 a “structural corrector” of p53 Y220C mutation that restores wild-type p53 function. According to PMV, “p53 Y220C mutations are found in approximately 1.0-1.5% of all cancers,” with PubMed suggesting breast and ovarian are among the highest frequency.",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ef3e1df6-6179-4359-8264-4687562f0aee",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.08,
        "w": 0.8,
        "x": 0.11,
        "y": 0.83
      },
      "kind": "source-note",
      "text": "5 PMVP, 10-K, 9-10, 3/1/2022; 6 PMVP, 10-K, 10, 3/1/2022; 7 The company sent us their January 2022 investor presentation...",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "0c00c7d6-58d8-45a5-aa02-708b44b30bbe",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.8,
        "x": 0.11,
        "y": 0.26
      },
      "kind": "title",
      "text": "PMV's Preclinical Laboratory Study Results Appear to Have Been Photoshopped to Demonstrate a Concept, Instead of Clear Results",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3289a4ea-8178-431f-9a38-13f1b9883549",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "fraud-exposure",
      "slug": null,
      "matchId": "8f4eb500-2aef-4ac5-bcac-3824765996c3",
      "evidence": "The slide explicitly claims data manipulation (photoshopping) to expose a contradiction in the company's scientific claims.",
      "confidence": 0.9
    }
  ],
  "arcBeats": [
    {
      "to": 12,
      "from": 3,
      "beatId": "f89a3578-3b10-48a0-a0dc-890f21967937",
      "arcName": "Overcoming the Monster",
      "arcSlug": "overcoming-monster",
      "beatName": "The Monster",
      "beatSlug": "overcoming-monster-the-monster",
      "evidence": "The document exposes contradictions and concerns regarding PMV Pharma's drug candidate.",
      "position": 0,
      "confidence": 0.8,
      "parentBeatName": "Hook",
      "parentBeatSlug": "hook"
    }
  ],
  "loops": [
    {
      "to": 9,
      "from": 4,
      "name": "Aha Moment",
      "slug": "03-aha-moment",
      "bestFor": "Data-heavy sections, research findings, analytical arguments",
      "matchId": "d5c00e43-039c-461c-a756-55cffee7cf74",
      "evidence": "The document highlights several concerns regarding PMV Pharma's preclinical study results.",
      "position": 0,
      "objective": "Raises concerns about the drug's selectivity and efficacy",
      "structure": "The Problem/Question -> What the Data Shows -> The Insight",
      "confidence": 0.7,
      "description": "Establish a tension, present data, then deliver the insight that changes everything"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}