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  "documentTitle": "PMV Pharmaceuticals (PMVP)",
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  "notes": "The slide uses a skeptical tone to challenge the efficacy of the drug based on the provided bar charts.",
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      "text": "We are not convinced that PC14586 can raise wild-type p53 activity high enough, for long enough, to effectively restore normal cell function or to result in durable tumor regression in humans.",
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      "text": "Wild-type p53 activity increases approximately five-fold ~8 hours after the first oral dose. However, by 24 hours, the activity is back down to pre-dose levels. The effect of the drug seems to be diminished after a few days of daily oral dosing.",
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      "text": "However, more important than the level of mutant p53, from a cancer-fighting mechanism standpoint, is the level of “restored” wild-type p53 active. This can be seen on the right in the figure below.",
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      "text": "Source: Form S/1 (September 2020)",
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