{ "docId": "019dd923-622c-750b-8b9a-4b91788fc785", "docSlug": "5fadb686cc03", "documentTitle": "Twist Bioscience (TWST)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2022-11-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.2941177, "pageNumber": 90, "pageCount": 236, "prevPage": 89, "nextPage": 91, "slideType": "expose_contradiction", "function": "expose_contradiction", "density": "overcrowded", "nDataPoints": 0, "notes": "The slide uses expert quotes to undermine the technical viability of the competitor's product.", "elementsJson": [ "paragraph", "quote_block", "footnote" ], "metadataConfidence": 0.95, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-4b91788fc785/90", "deckHref": "/decks/019dd923-622c-750b-8b9a-4b91788fc785", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-4b91788fc785.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-4b91788fc785#slide-90", "components": [ { "bbox": null, "kind": "callout", "text": "“the error rate is really, really high and that makes [the oligos] not useful” and is “way more expensive because they probably have to built it multiple times.”", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-0932-77cf-bfeb-66822a05a2fb", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.08, "w": 0.9, "x": 0.05, "y": 0.35 }, "kind": "list", "text": "Numerous ways that “very high error rates” get introduced during stitching; errors are so high that they turn a sequence into a completely different gene than intended; requires error correction", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "20d804d7-ab8d-4131-833c-6418c309d5f3", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.06, "w": 0.9, "x": 0.05, "y": 0.78 }, "kind": "list", "text": "“Really, really high” error rates from stitching short strands of oligos together which makes them “not useful”; “way more expensive” as Twist then has to re-manufacture “multiple times”", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "bc5ed2b1-6a98-4493-81fc-31eb2e542218", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.25, "w": 0.9, "x": 0.05, "y": 0.08 }, "kind": "paragraph", "text": "Another DNA synthesis expert, who was part of the founding team of Gen9 – which used the same Agilent “chip” as Twist and blew up – detailed numerous ways that “very high error rates” get introduced when oligos are stitched together, to the point that a sequence gets garbled into a completely different gene than intended. This results in expensive and time-consuming error-correction and re-work: “the error rate is really, really high and that makes [the oligos] not useful” and is “way more expensive because they probably have to built it multiple times.”", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "f394faf3-a390-4e3c-b660-97f686360f94", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.1, "w": 0.9, "x": 0.05, "y": 0.84 }, "kind": "quote", "text": "“The ability to take these short strands of these oligos and stitch them together and make them really, really long, that’s fine, except for the error rate is really, really high, and that makes them not useful. So, if you’re looking today at their numbers when you look at different services that they offer, you’ll see that besides the pools, they also offer specific genes. That is way more expensive because they probably have to build it multiple times.” –Founding member of Gen9, a virtually identical company to Twist that failed", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "5145f5b4-d393-47b4-9005-b83a4f259df0", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.35, "w": 0.9, "x": 0.05, "y": 0.43 }, "kind": "quote", "text": "“Short is generally 20 base pairs. You need 4 on each end at least to create the overlap in order to stitch them together, which means your payload is—each one of these is about 10 to 12 base pairs, which means you’re going to need a lot of little pieces. Every time you come to stitch those together, there’s a potential error. The wrong pieces may connect because they’re too close in what they look like. And so now, the wrong one is in the wrong place, and it starts to connect, and it’s a different whole set, and that happens often. Or, they overlap incorrectly, so even if you miss by one, it’s off. Those things are happening when you have this massive pool, and they’re all trying to come together, and you’re trying to create this reaction to bring them together. It ends up being what could be very high error rates because even if we’re off by one on that stitch, that’s one in, a 12 payload, it’s one every 20. It used to be that people were ordering an average of about 1500 to 2000 base pairs, but today, everybody’s claiming they can go up to 10,000. So, even in just 1000, there’s a good chance that you’re having 50 errors. That’s a lot. That’s a different gene. So, you have to have error correction that can come in and fix those.” –Founding member of Gen9, a virtually identical company to Twist", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "5b461f4a-f8b5-43a0-821c-34dbcb09d878", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "“Short is generally 20 base pairs. You need 4 on each end at least to create the overlap in order to stitch them together, which means your payload is—each one of these is about 10 to 12 base pairs, which means you’re going to need a lot of little pieces. Every time you come to stitch those together, there’s a potential error. The wrong pieces may connect because they’re too close in what they look like. And so now, the wrong one is in the wrong place, and it starts to connect, and it’s a different whole set, and that happens often. Or, they overlap incorrectly, so even if you miss by one, it’s off. Those things are happening when you have this massive pool, and they’re all trying to come together, and you’re trying to create this reaction to bring them together. It ends up being what could be very high error rates because even if we’re off by one on that stitch, that’s one in, a 12 payload, it’s one every 20. It used to be that people were ordering an average of about 1500 to 2000 base pairs, but today, everybody’s claiming they can go up to 10,000. So, even in just 1000, there’s a good chance that you’re having 50 errors. That’s a lot. That’s a different gene. So, you have to have error correction that can come in and fix those.” — Founding member of Gen9, a virtually identical company to Twist", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-0932-77cf-bfeb-6b5a98db290c", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.03, "w": 0.3, "x": 0.05, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "d96a7843-0ac1-4858-a6a6-55648eb315ff", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [], "loops": [ { "to": 100, "from": 90, "name": "Cost Of Inaction", "slug": "27-cost-of-inaction", "bestFor": "Urgent budget requests, compliance, risk mitigation", "matchId": "ba084e17-8baa-48c4-95ae-b7f2113f8ae2", "evidence": "Analysis of Twist's financial struggles and industry implications", "position": 1, "objective": "Highlight the consequences of Twist's actions", "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point", "confidence": 0.6, "description": "Quantify what happens if the audience does nothing" } ], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }