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  "documentTitle": "Twist Bioscience (TWST)",
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  "authorName": "Scorpion Capital",
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      "text": "The gene synthesis process is the same at Twist as it is everywhere else.",
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      "text": "\"Gene synthesis process is the same at Twist as it is everywhere else\" ... [quotes from former manager]",
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      "text": "“I was involved in the entire manufacturing process. All the way from extracting the oligos from their DNA synthesis chip to assembling those oligos into full-length genes through to the QC process and shipping out to the customers. I'll start off by just saying that the gene synthesis process is the same at Twist as it is everywhere else... The first step is to take the individual nucleotides, ATG, and C, and string those together into oligonucleotides, which are single-stranded DNA sequences around 50-200 base pairs, depending on what the error rate is. And then, they take those oligos and assemble them into approximately 2000 base pair fragments. Those fragments are then cloned into a replicating plasmid and put into E. coli. At that point, the E. coli can self-replicate those plasmids. That's a very common form to provide synthetic DNA to customers is in a replicating plasmid in an E. coli host. That's the deliverable.” — Former Twist manager in a manufacturing role, previously and currently employed by key competitors",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "An ex-Twist manager in a manufacturing role - \"I was involved in the entire manufacturing process\" - stated that the majority of their steps are the same as \"they were in the '90's\" and \"at the same point that all of the other vendors are at\"; that \"the gene synthesis process is the same at Twist as it is everywhere else\"; and that this is all \"pretty standard molecular biology technique...nothing special.\"",
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