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  "documentTitle": "Twist Bioscience (TWST)",
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      "text": "Twist is unable to scale; their chip's inability to produce sufficient amounts of single pieces of DNA causes major downstream manufacturing problems, resulting in high mutation rates; inconsistency; and poor turnaround times",
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      "text": "Twist's quality and consistency problems are most acute for their NGS product, which is low-end; “struggle” where “the big money is in the clinic”",
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      "text": "Twist heavily promotes its platform as high throughput, yet one customer, ex-employee, and competitor after another stated it the exact opposite, that it is only capable of making infinitesimal amounts of DNA that require time-consuming and expensive amplification which then compounds its quality control problems – “their main issue is scalability”; “they cannot produce large quantities of their single pieces of DNA, that causes all kinds of downstream application problems....they have repeatedly high mutation rates.” We note that quality and consistency issues are most acute for their NGS product, which is low-end, causing them to “struggle” where the “big money is in the clinic.”",
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      "text": "Q: “Which of their products does this affect? The NGS?”\nA: “That affects NGS. That’s most important to NGS.”\nQ: “So, their NGS product is basically the low end of the NGS market?”\nA: “I would say so. I think it’s a useful tool when you’re designing panels or if you’re doing research projects where you don’t necessarily care about really high consistency. But the big money is in the clinic, and that’s where I think they struggle.” – IDT ex-regional sales manager, left recently",
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      "text": "“I think their main issue is scalability. They cannot produce large quantities of their single pieces of DNA, and that causes all kinds of downstream application problems because they have to compensate for that in one way or another through methods like amplifying the material that they do have and tiling in the case of NGS. And consistency and turnaround time for double-stranded DNA constructs and keeping mutation rates down. They have repeatedly higher mutation rates in their double-stranded DNA.” –IDT ex-regional sales manager, left recently",
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      "text": "\"I think their main issue is scalability. They cannot produce large quantities of their single pieces of DNA, and that causes all kinds of downstream application problems because they have to compensate for that in one way or another through methods like amplifying the material that they do have and tiling in the case of NGS. And consistency and turnaround time for double-stranded DNA constructs and keeping mutation rates down. They have repeatedly higher mutation rates in their double-stranded DNA.\" — IDT ex-regional sales manager, left recently",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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